SNP Detail For rs4689355
1.Mapping Information
Human SNP ID rs4689355
Human chromosome chr4
Human SNP position 6175408
Pig chromosome chr8
Pig SNP position 2698978
2.Annotation Information
PubMed ID26031901
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/26031901
StudyGenome-wide association study of leukotriene modifier response in asthma.
Disease/TraitResponse to zileuton treatment in asthma (FEV1 change interaction)
Initial sample160 European and other ancestry zileuton-treated cases, 144 European and other ancestry placebo-controlled cases
Replication sample149 European and other ancestry zileuton-treated cases, 73 European and other ancestry placebo-controlled cases
Region4p16.1
Chromosome idchr4
Chromosome position6175408
Reported geneJAKMIP1
Mapped geneJAKMIP1
Upstream gene id
Downstream gene id
SNP gene ids152789
Upstream gene distance
Downstream gene distance
SNP risk allelers4689355-?
SNPsrs4689355
Merged
SNP id current4689355
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.0000005
Pvalue mlog6.30102999566398
P value text(Recessive model)
Or beta0.61
%95 Ciunit increase
PlatformIllumina [542562]
CNVN
Mapped traitFEV change measurement, response to zileuton, asthma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005921, http://www.ebi.ac.uk/efo/EFO_0007676, http://www.ebi.ac.uk/efo/EFO_0000270
Study accessionGCST002951