SNP Detail For rs459193
1.Mapping Information
Human SNP ID rs459193
Human chromosome chr5
Human SNP position 56510924
Pig chromosome chr16
Pig SNP position 37744864
2.Annotation Information
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region5q11.2
Chromosome idchr5
Chromosome position56510924
Reported geneANKRD55
Mapped geneRPL26P19 - LOC101928448
Upstream gene id441073
Downstream gene id101928448
SNP gene ids
Upstream gene distance5810
Downstream gene distance470
SNP risk allelers459193-A
SNPsrs459193
Merged0
SNP id current459193
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.2663
P value0.000000007
Pvalue mlog8.15490195998574
P value text(EA, men)
Or beta0.0325
%95 Ci[0.022-0.043] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region5q11.2
Chromosome idchr5
Chromosome position56510924
Reported geneANKRD55
Mapped geneRPL26P19 - LOC101928448
Upstream gene id441073
Downstream gene id101928448
SNP gene ids
Upstream gene distance5810
Downstream gene distance470
SNP risk allelers459193-A
SNPsrs459193
Merged0
SNP id current459193
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.2645
P value0.00000000002
Pvalue mlog10.698970004336
P value text(EA)
Or beta0.0259
%95 Ci[0.018-0.033] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region5q11.2
Chromosome idchr5
Chromosome position56510924
Reported geneANKRD55
Mapped geneRPL26P19 - LOC101928448
Upstream gene id441073
Downstream gene id101928448
SNP gene ids
Upstream gene distance5810
Downstream gene distance470
SNP risk allelers459193-A
SNPsrs459193
Merged0
SNP id current459193
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.2769
P value0.000000005
Pvalue mlog8.30102999566398
P value text(men)
Or beta0.0315
%95 Ci[0.021-0.042] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region5q11.2
Chromosome idchr5
Chromosome position56510924
Reported geneANKRD55
Mapped geneRPL26P19 - LOC101928448
Upstream gene id441073
Downstream gene id101928448
SNP gene ids
Upstream gene distance5810
Downstream gene distance470
SNP risk allelers459193-A
SNPsrs459193
Merged0
SNP id current459193
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.2779
P value0.000000000005
Pvalue mlog11.3010299956639
P value text
Or beta0.0255
%95 Ci[0.018-0.033] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782