SNP Detail For rs4506565
1.Mapping Information
Human SNP ID rs4506565
Human chromosome chr10
Human SNP position 112996282
Pig chromosome chr14
Pig SNP position 134626197
2.Annotation Information
PubMed ID17554300
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/17554300
StudyGenome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
Disease/TraitType 2 diabetes
Initial sample1,924 European ancestry cases, 2,938 European ancestry controls
Replication sample(see Zeggini 2007)
Region10q25.2
Chromosome idchr10
Chromosome position112996282
Reported geneTCF7L2
Mapped geneTCF7L2
Upstream gene id
Downstream gene id
SNP gene ids6934
Upstream gene distance
Downstream gene distance
SNP risk allelers4506565-T
SNPsrs4506565
Merged0
SNP id current4506565
Contextintron_variant
Intergenic0
Allele frequency0.32
P value0.000000000005
Pvalue mlog11.3010299956639
P value text
Or beta1.36
%95 Ci[1.20-1.54]
PlatformAffymetrix [469557]
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST000047
PubMed ID20081858
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20081858
StudyNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Disease/TraitFasting glucose-related traits
Initial sampleup to 46,186 European ancestry individuals
Replication sampleup to 76,558 European ancestry individuals
Region10q25.2
Chromosome idchr10
Chromosome position112996282
Reported geneTCF7L2
Mapped geneTCF7L2
Upstream gene id
Downstream gene id
SNP gene ids6934
Upstream gene distance
Downstream gene distance
SNP risk allelers4506565-T
SNPsrs4506565
Merged0
SNP id current4506565
Contextintron_variant
Intergenic0
Allele frequency0.31
P value0.00000001
Pvalue mlog8
P value text(FPG)
Or beta
%95 Ci
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitfasting blood glucose measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004465
Study accessionGCST000568