SNP Detail For rs4452313
1.Mapping Information
Human SNP ID rs4452313
Human chromosome chr3
Human SNP position 17005540
Pig chromosome chr13
Pig SNP position 4370324
2.Annotation Information
PubMed ID24390342
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/24390342
StudyGenetics of rheumatoid arthritis contributes to biology and drug discovery.
Disease/TraitRheumatoid arthritis
Initial sampleup to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls
Replication sampleup to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls
Region3p24.3
Chromosome idchr3
Chromosome position17005540
Reported genePLCL2
Mapped genePLCL2
Upstream gene id
Downstream gene id
SNP gene ids23228
Upstream gene distance
Downstream gene distance
SNP risk allelers4452313-T
SNPsrs4452313
Merged0
SNP id current4452313
Contextintron_variant
Intergenic0
Allele frequency0.29
P value0.00000000005
Pvalue mlog10.3010299956639
P value text(EA)
Or beta1.11
%95 Ci[1.08-1.15]
PlatformAffymetrix, Illumina [up to 9739303] (imputed)
CNVN
Mapped traitrheumatoid arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685
Study accessionGCST002318
PubMed ID24390342
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/24390342
StudyGenetics of rheumatoid arthritis contributes to biology and drug discovery.
Disease/TraitRheumatoid arthritis
Initial sampleup to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls
Replication sampleup to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls
Region3p24.3
Chromosome idchr3
Chromosome position17005540
Reported genePLCL2
Mapped genePLCL2
Upstream gene id
Downstream gene id
SNP gene ids23228
Upstream gene distance
Downstream gene distance
SNP risk allelers4452313-T
SNPsrs4452313
Merged0
SNP id current4452313
Contextintron_variant
Intergenic0
Allele frequency0.35
P value0.0000000002
Pvalue mlog9.69897000433601
P value text
Or beta1.09
%95 Ci[1.06-1.12]
PlatformAffymetrix, Illumina [up to 9739303] (imputed)
CNVN
Mapped traitrheumatoid arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685
Study accessionGCST002318