SNP Detail For rs445114
1.Mapping Information
Human SNP ID rs445114
Human chromosome chr8
Human SNP position 127310936
Pig chromosome chr4
Pig SNP position 13065208
2.Annotation Information
PubMed ID21743057
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21743057
StudyGenome-wide association study identifies new prostate cancer susceptibility loci.
Disease/TraitProstate cancer
Initial sample2,782 European ancestry cases, 4,458 European ancestry controls
Replication sample7,358 European ancestry cases, 6,732 European ancestry controls
Region8q24.21
Chromosome idchr8
Chromosome position127310936
Reported geneintergenic
Mapped geneCASC21, CASC8
Upstream gene id
Downstream gene id
SNP gene ids103021164, 727677
Upstream gene distance
Downstream gene distance
SNP risk allelers445114-T
SNPsrs445114
Merged0
SNP id current445114
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.0000005
Pvalue mlog6.30102999566398
P value text
Or beta1.22
%95 Ci[1.12-1.32]
PlatformIllumina [571243]
CNVN
Mapped traitprostate carcinoma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001663
Study accessionGCST001147
PubMed ID19767754
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/19767754
StudyGenome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
Disease/TraitProstate cancer
Initial sampleUp to 1,968 European ancestry cases, 35,382 European ancestry controls
Replication sampleUp to 11,806 European ancestry cases, 12,387 European ancestry controls
Region8q24.21
Chromosome idchr8
Chromosome position127310936
Reported geneintergenic
Mapped geneCASC21, CASC8
Upstream gene id
Downstream gene id
SNP gene ids103021164, 727677
Upstream gene distance
Downstream gene distance
SNP risk allelers445114-T
SNPsrs445114
Merged0
SNP id current445114
Contextintron_variant
Intergenic0
Allele frequency0.64
P value0.0000000005
Pvalue mlog9.30102999566398
P value text
Or beta1.14
%95 Ci[1.10-1.19]
PlatformIllumina [310520]
CNVN
Mapped traitprostate carcinoma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001663
Study accessionGCST000489
PubMed ID22219177
JournalCarcinogenesis
Linkwww.ncbi.nlm.nih.gov/pubmed/22219177
StudyA genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
Disease/TraitProstate cancer (gene x gene interaction)
Initial sample4,723 European ancestry cases, 4,792 European ancestry controls
Replication sampleNA
Region22q12.1 x 8q24.21
Chromosome idchr22 x 8
Chromosome position27456222 x 127310936
Reported geneMN1 x NR
Mapped geneLOC105372980 - LOC105372981 x CASC21, CASC8
Upstream gene id
Downstream gene id
SNP gene ids
Upstream gene distance
Downstream gene distance
SNP risk allelers6005451-? x rs445114-?
SNPsrs6005451 x rs445114
Merged0
SNP id current
Contextdownstream_gene_variant x intron_variant
Intergenic
Allele frequencyNR
P value0.000004
Pvalue mlog5.39794000867203
P value text
Or beta1.42
%95 Ci[1.22-1.65]
PlatformAffymetrix, Illumina [1117531] (imputed)
CNVN
Mapped traitprostate carcinoma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001663
Study accessionGCST001370