SNP Detail For rs441810
1.Mapping Information
Human SNP ID rs441810
Human chromosome chr21
Human SNP position 41326980
Pig chromosome chr13
Pig SNP position 214957680
2.Annotation Information
PubMed ID24941225
JournalPLoS One
Linkwww.ncbi.nlm.nih.gov/pubmed/24941225
StudyGenetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
Disease/TraitElevated serum carcinoembryonic antigen levels
Initial sample1,999 Chinese ancestry individuals
Replication sampleNA
Region21q22.3
Chromosome idchr21
Chromosome position41326980
Reported geneFAM3B
Mapped geneFAM3B
Upstream gene id
Downstream gene id
SNP gene ids54097
Upstream gene distance
Downstream gene distance
SNP risk allelers441810-?
SNPsrs441810
Merged0
SNP id current441810
Contextintron_variant
Intergenic0
Allele frequency
P value0.00000002
Pvalue mlog7.69897000433601
P value text
Or beta
%95 Ci
PlatformIllumina [709211] (imputed)
CNVN
Mapped traitserum carcinoembryonic antigen measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005760
Study accessionGCST002485
PubMed ID23300138
JournalGut
Linkwww.ncbi.nlm.nih.gov/pubmed/23300138
StudyA genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
Disease/TraitTumor biomarkers
Initial sample3,451 Han Chinese ancestry individuals
Replication sample10,326 Chinese ancestry individuals
Region21q22.3
Chromosome idchr21
Chromosome position41326980
Reported geneFAM3B
Mapped geneFAM3B
Upstream gene id
Downstream gene id
SNP gene ids54097
Upstream gene distance
Downstream gene distance
SNP risk allelers441810-G
SNPsrs441810
Merged0
SNP id current441810
Contextintron_variant
Intergenic0
Allele frequency0.24
P value3E-22
Pvalue mlog21.5228787452803
P value text(CEA)
Or beta0.069
%95 Ci[0.040-0.098] ng/ml increase
PlatformAffymetrix, Illumina [NR] (imputed)
CNVN
Mapped traitcancer biomarker measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005127
Study accessionGCST001808