SNP Detail For rs4373814
1.Mapping Information
Human SNP ID rs4373814
Human chromosome chr10
Human SNP position 18131043
Pig chromosome chr10
Pig SNP position 49142784
2.Annotation Information
PubMed ID21909115
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/21909115
StudyGenetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Disease/TraitSystolic blood pressure
Initial sample69,395 European ancestry individuals
Replication sampleUp to 133,361 European ancestry individuals
Region10p12.33
Chromosome idchr10
Chromosome position18131043
Reported geneCACNB2
Mapped geneSLC39A12 - CACNB2
Upstream gene id221074
Downstream gene id783
SNP gene ids
Upstream gene distance87751
Downstream gene distance9634
SNP risk allelers4373814-G
SNPsrs4373814
Merged0
SNP id current4373814
Contextintergenic_variant
Intergenic1
Allele frequency0.55
P value0.00000000005
Pvalue mlog10.3010299956639
P value text
Or beta0.373
%95 Ci[NR] mmHg decrease
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitsystolic blood pressure
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006335
Study accessionGCST001227
PubMed ID21909115
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/21909115
StudyGenetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Disease/TraitDiastolic blood pressure
Initial sample69,395 European ancestry individuals
Replication sampleUp to 133,361 European ancestry individuals
Region10p12.33
Chromosome idchr10
Chromosome position18131043
Reported geneCACNB2
Mapped geneSLC39A12 - CACNB2
Upstream gene id221074
Downstream gene id783
SNP gene ids
Upstream gene distance87751
Downstream gene distance9634
SNP risk allelers4373814-G
SNPsrs4373814
Merged0
SNP id current4373814
Contextintergenic_variant
Intergenic1
Allele frequency0.55
P value0.0000000004
Pvalue mlog9.39794000867203
P value text
Or beta0.218
%95 Ci[NR] mmHg decrease
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitdiastolic blood pressure
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006336
Study accessionGCST001228
PubMed ID21909115
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/21909115
StudyGenetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Disease/TraitHypertension
Initial sample69,395 European ancestry individuals
Replication sampleUp to 133,361 European ancestry individuals
Region10p12.33
Chromosome idchr10
Chromosome position18131043
Reported geneCACNB2
Mapped geneSLC39A12 - CACNB2
Upstream gene id221074
Downstream gene id783
SNP gene ids
Upstream gene distance87751
Downstream gene distance9634
SNP risk allelers4373814-G
SNPsrs4373814
Merged0
SNP id current4373814
Contextintergenic_variant
Intergenic1
Allele frequency0.55
P value0.00000009
Pvalue mlog7.04575749056067
P value text
Or beta0.046
%95 Ci[NR] unit decrease
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traithypertension
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000537
Study accessionGCST001238