SNP Detail For rs419076
1.Mapping Information
Human SNP ID rs419076
Human chromosome chr3
Human SNP position 169383098
Pig chromosome chr13
Pig SNP position 116760605
2.Annotation Information
PubMed ID21909110
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21909110
StudyGenome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
Disease/TraitBlood pressure
Initial sample74,064 European ancestry individuals
Replication sample48,607 European ancestry individuals
Region3q26.2
Chromosome idchr3
Chromosome position169383098
Reported geneMECOM
Mapped geneMECOM
Upstream gene id
Downstream gene id
SNP gene ids2122
Upstream gene distance
Downstream gene distance
SNP risk allelers419076-T
SNPsrs419076
Merged0
SNP id current419076
Contextintron_variant
Intergenic0
Allele frequency0.44
P value0.0000000000008
Pvalue mlog12.096910013008
P value text(Mean Arterial Pressure)
Or beta0.34
%95 Ci[0.25-0.43] mmHg increase
PlatformAffymetrix, Illumina, Perlegen [NR] (imputed)
CNVN
Mapped traitmean arterial pressure
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006340
Study accessionGCST001236
PubMed ID21909115
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/21909115
StudyGenetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Disease/TraitDiastolic blood pressure
Initial sample69,395 European ancestry individuals
Replication sampleUp to 133,361 European ancestry individuals
Region3q26.2
Chromosome idchr3
Chromosome position169383098
Reported geneMECOM
Mapped geneMECOM
Upstream gene id
Downstream gene id
SNP gene ids2122
Upstream gene distance
Downstream gene distance
SNP risk allelers419076-T
SNPsrs419076
Merged0
SNP id current419076
Contextintron_variant
Intergenic0
Allele frequency0.47
P value0.000000000002
Pvalue mlog11.698970004336
P value text
Or beta0.241
%95 Ci[NR] mmHg increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitdiastolic blood pressure
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006336
Study accessionGCST001228
PubMed ID21909115
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/21909115
StudyGenetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Disease/TraitSystolic blood pressure
Initial sample69,395 European ancestry individuals
Replication sampleUp to 133,361 European ancestry individuals
Region3q26.2
Chromosome idchr3
Chromosome position169383098
Reported geneMECOM
Mapped geneMECOM
Upstream gene id
Downstream gene id
SNP gene ids2122
Upstream gene distance
Downstream gene distance
SNP risk allelers419076-T
SNPsrs419076
Merged0
SNP id current419076
Contextintron_variant
Intergenic0
Allele frequency0.47
P value0.0000000000002
Pvalue mlog12.698970004336
P value text
Or beta0.409
%95 Ci[NR] mmHg increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitsystolic blood pressure
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006335
Study accessionGCST001227