SNP Detail For rs4081724
1.Mapping Information
Human SNP ID rs4081724
Human chromosome chr19
Human SNP position 33334040
Pig chromosome chr6
Pig SNP position 38661192
2.Annotation Information
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region19q13.11
Chromosome idchr19
Chromosome position33334040
Reported geneCEBPA
Mapped geneLOC105372369 - AKR1B1P7
Upstream gene id105372369
Downstream gene id126242
SNP gene ids
Upstream gene distance10837
Downstream gene distance26086
SNP risk allelers4081724-G
SNPsrs4081724
Merged0
SNP id current4081724
Contextintergenic_variant
Intergenic1
Allele frequency0.8488
P value0.0000009
Pvalue mlog6.04575749056067
P value text(EA, women)
Or beta0.0327
%95 Ci[0.02-0.046] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region19q13.11
Chromosome idchr19
Chromosome position33334040
Reported geneCEBPA
Mapped geneLOC105372369 - AKR1B1P7
Upstream gene id105372369
Downstream gene id126242
SNP gene ids
Upstream gene distance10837
Downstream gene distance26086
SNP risk allelers4081724-G
SNPsrs4081724
Merged0
SNP id current4081724
Contextintergenic_variant
Intergenic1
Allele frequency0.8522
P value0.0000001
Pvalue mlog7
P value text(EA, men)
Or beta0.0391
%95 Ci[0.025-0.054] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region19q13.11
Chromosome idchr19
Chromosome position33334040
Reported geneCEBPA
Mapped geneLOC105372369 - AKR1B1P7
Upstream gene id105372369
Downstream gene id126242
SNP gene ids
Upstream gene distance10837
Downstream gene distance26086
SNP risk allelers4081724-G
SNPsrs4081724
Merged0
SNP id current4081724
Contextintergenic_variant
Intergenic1
Allele frequency0.8512
P value0.000000000007
Pvalue mlog11.1549019599857
P value text(EA)
Or beta0.0347
%95 Ci[0.025-0.045] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region19q13.11
Chromosome idchr19
Chromosome position33334040
Reported geneCEBPA
Mapped geneLOC105372369 - AKR1B1P7
Upstream gene id105372369
Downstream gene id126242
SNP gene ids
Upstream gene distance10837
Downstream gene distance26086
SNP risk allelers4081724-G
SNPsrs4081724
Merged0
SNP id current4081724
Contextintergenic_variant
Intergenic1
Allele frequency0.8536
P value0.0000003
Pvalue mlog6.52287874528033
P value text(men)
Or beta0.0378
%95 Ci[0.023-0.052] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region19q13.11
Chromosome idchr19
Chromosome position33334040
Reported geneCEBPA
Mapped geneLOC105372369 - AKR1B1P7
Upstream gene id105372369
Downstream gene id126242
SNP gene ids
Upstream gene distance10837
Downstream gene distance26086
SNP risk allelers4081724-G
SNPsrs4081724
Merged0
SNP id current4081724
Contextintergenic_variant
Intergenic1
Allele frequency0.8504
P value0.0000005
Pvalue mlog6.30102999566398
P value text(women)
Or beta0.0334
%95 Ci[0.02-0.047] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region19q13.11
Chromosome idchr19
Chromosome position33334040
Reported geneCEBPA
Mapped geneLOC105372369 - AKR1B1P7
Upstream gene id105372369
Downstream gene id126242
SNP gene ids
Upstream gene distance10837
Downstream gene distance26086
SNP risk allelers4081724-G
SNPsrs4081724
Merged0
SNP id current4081724
Contextintergenic_variant
Intergenic1
Allele frequency0.8529
P value0.000000000005
Pvalue mlog11.3010299956639
P value text
Or beta0.0347
%95 Ci[0.025-0.044] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782