SNP Detail For rs3865444
1.Mapping Information
Human SNP ID rs3865444
Human chromosome chr19
Human SNP position 51224706
Pig chromosome chr6
Pig SNP position 51736911
2.Annotation Information
PubMed ID21460841
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21460841
StudyCommon variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer__s disease.
Disease/TraitAlzheimer__s disease (late onset)
Initial sample8,309 European ancestry cases, 7,366 European ancestry controls
Replication sample10,523 European ancestry cases, 28,231 European ancestry controls
Region19q13.41
Chromosome idchr19
Chromosome position51224706
Reported geneCD33
Mapped geneCD33
Upstream gene id
Downstream gene id
SNP gene ids945
Upstream gene distance
Downstream gene distance
SNP risk allelers3865444-?
SNPsrs3865444
Merged0
SNP id current3865444
Contextupstream_gene_variant
Intergenic0
Allele frequency0.7
P value0.000000002
Pvalue mlog8.69897000433601
P value text
Or beta1.1
%95 Ci[1.08-1.14]
PlatformAffymetrix, Illumina [2324889] (imputed)
CNVN
Mapped traitAlzheimers disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000249
Study accessionGCST001026
PubMed ID24162737
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24162737
StudyMeta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer__s disease.
Disease/TraitAlzheimer__s disease (late onset)
Initial sample17,008 European ancestry cases, 37,154 European ancestry controls
Replication sample8,572 European ancestry cases, 11,312 European ancestry controls
Region19q13.41
Chromosome idchr19
Chromosome position51224706
Reported geneCD33
Mapped geneCD33
Upstream gene id
Downstream gene id
SNP gene ids945
Upstream gene distance
Downstream gene distance
SNP risk allelers3865444-C
SNPsrs3865444
Merged0
SNP id current3865444
Contextupstream_gene_variant
Intergenic0
Allele frequency0.693
P value0.000003
Pvalue mlog5.52287874528033
P value text
Or beta1.06
%95 Ci[1.04-1.1]
PlatformIllumina [7055881] (imputed)
CNVN
Mapped traitAlzheimers disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000249
Study accessionGCST002245