Human SNP ID | rs3845905 |
---|---|
Human chromosome | chr3 |
Human SNP position | 66475539 |
Pig chromosome | chr13 |
Pig SNP position | 52743121 |
PubMed ID | 23648065 |
---|---|
Journal | Cancer Sci |
Link | www.ncbi.nlm.nih.gov/pubmed/23648065 |
Study | Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. |
Disease/Trait | Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) |
Initial sample | 428 Japanese ancestry cases, 743 Japanese ancestry controls |
Replication sample | NA |
Region | 3p14.1 |
Chromosome id | chr3 |
Chromosome position | 66475539 |
Reported gene | LRIG1 |
Mapped gene | LRIG1 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 26018 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs3845905-G |
SNPs | rs3845905 |
Merged | 0 |
SNP id current | 3845905 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.85 |
P value | 0.000004 |
Pvalue mlog | 5.39794000867203 |
P value text | (Allelic model) |
Or beta | 1.894 |
%95 Ci | [1.433-2.503] |
Platform | Illumina [733202] |
CNV | N |
Mapped trait | response to platinum based chemotherapy, response to antineoplastic agent |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004647, http://purl.obolibrary.org/obo/GO_0097327 |
Study accession | GCST001998 |
PubMed ID | 23648065 |
Journal | Cancer Sci |
Link | www.ncbi.nlm.nih.gov/pubmed/23648065 |
Study | Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. |
Disease/Trait | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) |
Initial sample | 261 Japanese ancestry cases, 262 Japanese ancestry controls |
Replication sample | NA |
Region | 3p14.1 |
Chromosome id | chr3 |
Chromosome position | 66475539 |
Reported gene | LRIG1 |
Mapped gene | LRIG1 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 26018 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs3845905-G |
SNPs | rs3845905 |
Merged | 0 |
SNP id current | 3845905 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.828 |
P value | 0.000006 |
Pvalue mlog | 5.22184874961635 |
P value text | (Allelic model) |
Or beta | 2.433 |
%95 Ci | [1.645-3.598] |
Platform | Illumina [733202] |
CNV | N |
Mapped trait | response to carboplatin, response to antineoplastic agent |
Mapped trait URI | http://purl.obolibrary.org/obo/GO_0097328, http://purl.obolibrary.org/obo/GO_0097327 |
Study accession | GCST002004 |