SNP Detail For rs3845905
1.Mapping Information
Human SNP ID rs3845905
Human chromosome chr3
Human SNP position 66475539
Pig chromosome chr13
Pig SNP position 52743121
2.Annotation Information
PubMed ID23648065
JournalCancer Sci
Linkwww.ncbi.nlm.nih.gov/pubmed/23648065
StudyGenome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
Disease/TraitAdverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs)
Initial sample428 Japanese ancestry cases, 743 Japanese ancestry controls
Replication sampleNA
Region3p14.1
Chromosome idchr3
Chromosome position66475539
Reported geneLRIG1
Mapped geneLRIG1
Upstream gene id
Downstream gene id
SNP gene ids26018
Upstream gene distance
Downstream gene distance
SNP risk allelers3845905-G
SNPsrs3845905
Merged0
SNP id current3845905
Contextintron_variant
Intergenic0
Allele frequency0.85
P value0.000004
Pvalue mlog5.39794000867203
P value text(Allelic model)
Or beta1.894
%95 Ci[1.433-2.503]
PlatformIllumina [733202]
CNVN
Mapped traitresponse to platinum based chemotherapy, response to antineoplastic agent
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004647, http://purl.obolibrary.org/obo/GO_0097327
Study accessionGCST001998
PubMed ID23648065
JournalCancer Sci
Linkwww.ncbi.nlm.nih.gov/pubmed/23648065
StudyGenome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
Disease/TraitAdverse response to chemotherapy (neutropenia/leucopenia) (carboplatin)
Initial sample261 Japanese ancestry cases, 262 Japanese ancestry controls
Replication sampleNA
Region3p14.1
Chromosome idchr3
Chromosome position66475539
Reported geneLRIG1
Mapped geneLRIG1
Upstream gene id
Downstream gene id
SNP gene ids26018
Upstream gene distance
Downstream gene distance
SNP risk allelers3845905-G
SNPsrs3845905
Merged0
SNP id current3845905
Contextintron_variant
Intergenic0
Allele frequency0.828
P value0.000006
Pvalue mlog5.22184874961635
P value text(Allelic model)
Or beta2.433
%95 Ci[1.645-3.598]
PlatformIllumina [733202]
CNVN
Mapped traitresponse to carboplatin, response to antineoplastic agent
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0097328, http://purl.obolibrary.org/obo/GO_0097327
Study accessionGCST002004