SNP Detail For rs3824662
1.Mapping Information
Human SNP ID rs3824662
Human chromosome chr10
Human SNP position 8062245
Pig chromosome chr10
Pig SNP position 69594822
2.Annotation Information
PubMed ID23996088
JournalBlood
Linkwww.ncbi.nlm.nih.gov/pubmed/23996088
StudyVariation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype.
Disease/TraitAcute lymphoblastic leukemia (B-cell precursor)
Initial sample1,658 European ancestry child cases, 4,723 European ancestry controls
Replication sample1,449 European ancestry child cases, 1,488 European ancestry controls
Region10p14
Chromosome idchr10
Chromosome position8062245
Reported geneGATA3
Mapped geneGATA3
Upstream gene id
Downstream gene id
SNP gene ids2625
Upstream gene distance
Downstream gene distance
SNP risk allelers3824662-T
SNPsrs3824662
Merged0
SNP id current3824662
Contextintron_variant
Intergenic0
Allele frequency0.17
P value0.000000000009
Pvalue mlog11.0457574905606
P value text
Or beta1.31
%95 Ci[1.21-1.41]
PlatformIllumina [382776] (imputed)
CNVN
Mapped traitB-cell acute lymphoblastic leukemia
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000094
Study accessionGCST002158
PubMed ID25468567
JournalBlood
Linkwww.ncbi.nlm.nih.gov/pubmed/25468567
StudyA genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults.
Disease/TraitAcute lymphoblastic leukemia (adolescents and young adults)
Initial sample99 European ancestry cases, 1,381 European ancestry controls, 15 African American cases, 1,363 African American controls, 76 Hispanic cases, 1,008 Hispanic controls, 118 other ancestry cases, 2,909 other ancestry controls
Replication sample72 European ancestry cases, 3,667 European ancestry controls, 9 African American cases, 1,076 African American controls, 34 Hispanic cases, 501 Hispanic controls, 47 other ancestry cases, 511 other ancestry controls
Region10p14
Chromosome idchr10
Chromosome position8062245
Reported geneGATA3
Mapped geneGATA3
Upstream gene id
Downstream gene id
SNP gene ids2625
Upstream gene distance
Downstream gene distance
SNP risk allelers3824662-A
SNPsrs3824662
Merged0
SNP id current3824662
Contextintron_variant
Intergenic0
Allele frequency0.2
P value0.0000000003
Pvalue mlog9.52287874528033
P value text
Or beta1.77
%95 Ci[1.48-2.12]
PlatformAffymetrix [635297]
CNVN
Mapped traitacute lymphoblastic leukemia
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000220
Study accessionGCST002713