SNP Detail For rs3812141
1.Mapping Information
Human SNP ID rs3812141
Human chromosome chr6
Human SNP position 83524425
Pig chromosome chr1
Pig SNP position 92967743
2.Annotation Information
PubMed ID26031901
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/26031901
StudyGenome-wide association study of leukotriene modifier response in asthma.
Disease/TraitResponse to zileuton treatment in asthma (FEV1 change interaction)
Initial sample160 European and other ancestry zileuton-treated cases, 144 European and other ancestry placebo-controlled cases
Replication sample149 European and other ancestry zileuton-treated cases, 73 European and other ancestry placebo-controlled cases
Region6q14.2
Chromosome idchr6
Chromosome position83524425
Reported genePRSS35
Mapped genePRSS35
Upstream gene id
Downstream gene id
SNP gene ids167681
Upstream gene distance
Downstream gene distance
SNP risk allelers3812141-?
SNPsrs3812141
Merged
SNP id current3812141
Contextsynonymous_variant
Intergenic0
Allele frequencyNR
P value0.0000008
Pvalue mlog6.09691001300805
P value text(Additive model)
Or beta0.5
%95 Ciunit decrease
PlatformIllumina [542562]
CNVN
Mapped traitFEV change measurement, response to zileuton, asthma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005921, http://www.ebi.ac.uk/efo/EFO_0007676, http://www.ebi.ac.uk/efo/EFO_0000270
Study accessionGCST002951