SNP Detail For rs3736830
1.Mapping Information
Human SNP ID rs3736830
Human chromosome chr13
Human SNP position 49732085
Pig chromosome chr11
Pig SNP position 18098847
2.Annotation Information
PubMed ID22267201
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22267201
StudyMeta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
Disease/TraitMenopause (age at onset)
Initial sample38,968 European ancestry female individuals
Replication sampleUp to 14,435 European ancestry female individuals
Region13q14.2
Chromosome idchr13
Chromosome position49732085
Reported geneKPNA3
Mapped geneKPNA3
Upstream gene id
Downstream gene id
SNP gene ids3839
Upstream gene distance
Downstream gene distance
SNP risk allelers3736830-G
SNPsrs3736830
Merged0
SNP id current3736830
Contextintron_variant
Intergenic0
Allele frequency0.157
P value0.00000009
Pvalue mlog7.04575749056067
P value text
Or beta0.18
%95 Ci[0.11-0.25] years decrease
PlatformAffymetrix, Illumina [2551160] (imputed)
CNVN
Mapped traitage at menopause
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004704
Study accessionGCST001381
PubMed ID25574825
JournalAm J Hum Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25574825
StudyGenome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
Disease/TraitInflammatory skin disease
Initial sample2,079 European ancestry atopic dermatitis cases, 4,212 European ancestry psoriasis cases, 11,899 European ancestry controls
Replication sampleNA
Region13q14.2
Chromosome idchr13
Chromosome position49732085
Reported geneKPNA3
Mapped geneKPNA3
Upstream gene id
Downstream gene id
SNP gene ids3839
Upstream gene distance
Downstream gene distance
SNP risk allelers3736830-?
SNPsrs3736830
Merged0
SNP id current3736830
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.000009
Pvalue mlog5.04575749056067
P value text(Shared)
Or beta
%95 Ci
PlatformAffymetrix, Illumina [~ 5200000]
CNVN
Mapped traitatopic eczema, psoriasis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000274, http://www.ebi.ac.uk/efo/EFO_0000676
Study accessionGCST002740