SNP Detail For rs3734729
1.Mapping Information
Human SNP ID rs3734729
Human chromosome chr6
Human SNP position 150249731
Pig chromosome chr1
Pig SNP position 17996225
2.Annotation Information
PubMed ID21946350
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21946350
StudyGenome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Disease/TraitPulmonary function
Initial sample48,201 European ancestry individuals
Replication sample46,411 European ancestry individuals
Region6q25.1
Chromosome idchr6
Chromosome position150249731
Reported genePPP1R14C
Mapped genePPP1R14C
Upstream gene id
Downstream gene id
SNP gene ids81706
Upstream gene distance
Downstream gene distance
SNP risk allelers3734729-G
SNPsrs3734729
Merged0
SNP id current3734729
Context3_prime_UTR_variant
Intergenic0
Allele frequencyNR
P value0.000004
Pvalue mlog5.39794000867203
P value text(FEV1)
Or beta0.055
%95 Ci[0.031-0.079] unit decrease
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitpulmonary function measurement, forced expiratory volume
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003892, http://www.ebi.ac.uk/efo/EFO_0004314
Study accessionGCST001251
PubMed ID23284291
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23284291
StudyGenome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
Disease/TraitPulmonary function (interaction)
Initial sample50,047 European ancestry individuals
Replication sampleNA
Region6q25.1
Chromosome idchr6
Chromosome position150249731
Reported genePPP1R1
Mapped genePPP1R14C
Upstream gene id
Downstream gene id
SNP gene ids81706
Upstream gene distance
Downstream gene distance
SNP risk allelers3734729-A
SNPsrs3734729
Merged0
SNP id current3734729
Context3_prime_UTR_variant
Intergenic0
Allele frequencyNR
P value0.0000004
Pvalue mlog6.39794000867203
P value text(FEV1, Ever-smoking)
Or beta
%95 Ci
PlatformNR [~ 2500000] (imputed)
CNVN
Mapped traitforced expiratory volume
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004314
Study accessionGCST001784
PubMed ID23284291
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23284291
StudyGenome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
Disease/TraitPulmonary function (interaction)
Initial sample50,047 European ancestry individuals
Replication sampleNA
Region6q25.1
Chromosome idchr6
Chromosome position150249731
Reported genePPP1R1
Mapped genePPP1R14C
Upstream gene id
Downstream gene id
SNP gene ids81706
Upstream gene distance
Downstream gene distance
SNP risk allelers3734729-A
SNPsrs3734729
Merged0
SNP id current3734729
Context3_prime_UTR_variant
Intergenic0
Allele frequencyNR
P value0.0000007
Pvalue mlog6.15490195998574
P value text(FEV1, Pack-years)
Or beta
%95 Ci
PlatformNR [~ 2500000] (imputed)
CNVN
Mapped traitforced expiratory volume
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004314
Study accessionGCST001784