SNP Detail For rs33980500
1.Mapping Information
Human SNP ID rs33980500
Human chromosome chr6
Human SNP position 111592059
Pig chromosome chr1
Pig SNP position 87084665
2.Annotation Information
PubMed ID20953186
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20953186
StudyCommon variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.
Disease/TraitPsoriatic arthritis
Initial sample572 European ancestry cases, 888 European ancestry controls
Replication sampleUp to 1,761 European ancestry cases, 3,727 European ancestry controls
Region6q21
Chromosome idchr6
Chromosome position111592059
Reported geneTRAF3IP2
Mapped geneTRAF3IP2-AS1, TRAF3IP2
Upstream gene id
Downstream gene id
SNP gene ids643749, 10758
Upstream gene distance
Downstream gene distance
SNP risk allelers33980500-T
SNPsrs33980500
Merged0
SNP id current33980500
Contextmissense_variant
Intergenic0
Allele frequency0.07
P value1E-20
Pvalue mlog20
P value text
Or beta1.95
%95 Ci[1.69-2.24]
PlatformAffymetrix [1585307] (imputed)
CNVN
Mapped traitpsoriatic arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003778
Study accessionGCST000835
PubMed ID20953188
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20953188
StudyGenome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
Disease/TraitPsoriasis
Initial sample472 European ancestry cases, 1,146 European ancestry controls
Replication sample2,668, European ancestry cases, 762 French Canadian founder population cases, 2,585 cases, 3,485 European ancestry controls, 994 French Canadian founder population controls, 2,412 controls
Region6q21
Chromosome idchr6
Chromosome position111592059
Reported geneTRAF3IP2
Mapped geneTRAF3IP2-AS1, TRAF3IP2
Upstream gene id
Downstream gene id
SNP gene ids643749, 10758
Upstream gene distance
Downstream gene distance
SNP risk allelers33980500-T
SNPsrs33980500
Merged0
SNP id current33980500
Contextmissense_variant
Intergenic0
Allele frequency0.08
P value0.0000000000000001
Pvalue mlog16
P value text
Or beta
%95 Ci
PlatformIllumina [2339118] (imputed)
CNVN
Mapped traitpsoriasis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000676
Study accessionGCST000836
PubMed ID26626624
JournalAm J Hum Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26626624
StudyGenome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
Disease/TraitPsoriasis vulgaris
Initial sample4,007 European ancestry cases, 4,934 European ancestry controls
Replication sampleup to 9,075 European ancestry cases, up to European ancestry 12,726 controls
Region6q21
Chromosome idchr6
Chromosome position111592059
Reported geneTRAF3IP2
Mapped geneTRAF3IP2-AS1, TRAF3IP2
Upstream gene id
Downstream gene id
SNP gene ids643749, 10758
Upstream gene distance
Downstream gene distance
SNP risk allelers33980500-T
SNPsrs33980500
Merged0
SNP id current33980500
Contextmissense_variant
Intergenic0
Allele frequencyNR
P value1E-23
Pvalue mlog23
P value text
Or beta1.44
%95 CiNR
PlatformIllumina [up to 11532644] (imputed)
CNVN
Mapped trait
Mapped trait URI
Study accessionGCST003268
PubMed ID26626624
JournalAm J Hum Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26626624
StudyGenome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
Disease/TraitPsoriatic arthritis
Initial sample1,946 European ancestry cases, 4,934 European ancestry controls
Replication sampleup to 2,883 European ancestry cases, up to 14,179 European ancestry controls
Region6q21
Chromosome idchr6
Chromosome position111592059
Reported geneTRAF3IP2
Mapped geneTRAF3IP2-AS1, TRAF3IP2
Upstream gene id
Downstream gene id
SNP gene ids643749, 10758
Upstream gene distance
Downstream gene distance
SNP risk allelers33980500-T
SNPsrs33980500
Merged0
SNP id current33980500
Contextmissense_variant
Intergenic0
Allele frequencyNR
P value0.00000000000000001
Pvalue mlog17
P value text
Or beta1.599
%95 CiNR
PlatformIllumina [11532644] (imputed)
CNVN
Mapped traitpsoriatic arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003778
Study accessionGCST003270