SNP Detail For rs314277
1.Mapping Information
Human SNP ID rs314277
Human chromosome chr6
Human SNP position 104959787
Pig chromosome chr1
Pig SNP position 80447203
2.Annotation Information
PubMed ID19448621
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/19448621
StudyGenome-wide association studies identify loci associated with age at menarche and age at natural menopause.
Disease/TraitMenarche and menopause (age at onset)
Initial sample17,438 European ancestry female individuals
Replication sampleNA
Region6q16.3
Chromosome idchr6
Chromosome position104959787
Reported geneLIN28B
Mapped geneLIN28B
Upstream gene id
Downstream gene id
SNP gene ids389421
Upstream gene distance
Downstream gene distance
SNP risk allelers314277-A
SNPsrs314277
Merged0
SNP id current314277
Contextintron_variant
Intergenic0
Allele frequency0.14
P value0.0000000000003
Pvalue mlog12.5228787452803
P value text(age at menarche)
Or beta0.16
%95 Ci[0.12-0.20] years increase
PlatformIllumina [317759]
CNVN
Mapped traitage at menarche
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004703
Study accessionGCST000403
PubMed ID20303062
JournalAm J Hum Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20303062
StudyA variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure.
Disease/TraitDigit length ratio
Initial sample2,889 European ancestry children and adolescents
Replication sample3,659 European ancestry children
Region6q16.3
Chromosome idchr6
Chromosome position104959787
Reported geneLIN28B
Mapped geneLIN28B
Upstream gene id
Downstream gene id
SNP gene ids389421
Upstream gene distance
Downstream gene distance
SNP risk allelers314277-A
SNPsrs314277
Merged0
SNP id current314277
Contextintron_variant
Intergenic0
Allele frequency0.15
P value0.000002
Pvalue mlog5.69897000433601
P value text
Or beta0.63
%95 Ci[0.41-0.85] mean 2D:4D increase
PlatformIllumina [310613]
CNVN
Mapped traitdigit length ratio
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004841
Study accessionGCST000630
PubMed ID18391950
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/18391950
StudyIdentification of ten loci associated with height highlights new biological pathways in human growth.
Disease/TraitHeight
Initial sample15,821 European ancestry individuals
Replication sampleUp to 17,801 European ancestry individuals
Region6q16.3
Chromosome idchr6
Chromosome position104959787
Reported geneLIN28B
Mapped geneLIN28B
Upstream gene id
Downstream gene id
SNP gene ids389421
Upstream gene distance
Downstream gene distance
SNP risk allelers314277-A
SNPsrs314277
Merged0
SNP id current314277
Contextintron_variant
Intergenic0
Allele frequency0.13
P value0.00000001
Pvalue mlog8
P value text
Or beta0.41
%95 Ci[0.26-0.59] cm increase
PlatformAffymetrix, Illumina [2260683] (imputed)
CNVN
Mapped traitbody height
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004339
Study accessionGCST000176