SNP Detail For rs314276
1.Mapping Information
Human SNP ID rs314276
Human chromosome chr6
Human SNP position 104960124
Pig chromosome chr1
Pig SNP position 80447558
2.Annotation Information
PubMed ID19448623
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/19448623
StudyGenetic variation in LIN28B is associated with the timing of puberty.
Disease/TraitMenarche (age at onset)
Initial sample4,714 European ancestry female individuals
Replication sample16,373 European ancestry female individuals
Region6q16.3
Chromosome idchr6
Chromosome position104960124
Reported geneLIN28B
Mapped geneLIN28B
Upstream gene id
Downstream gene id
SNP gene ids389421
Upstream gene distance
Downstream gene distance
SNP risk allelers314276-C
SNPsrs314276
Merged0
SNP id current314276
Contextintron_variant
Intergenic0
Allele frequency0.67
P value0.0000000000000004
Pvalue mlog15.397940008672
P value text
Or beta0.14
%95 Ci[0.11-0.17] year decrease
PlatformAffymetrix [up to 390631]
CNVN
Mapped traitage at menarche
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004703
Study accessionGCST000405
PubMed ID24770850
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24770850
StudyGenome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.
Disease/TraitPuberty onset
Initial sample6,147 European ancestry girls, 3,769 European ancestry boys
Replication sampleUp to 1,376 European ancestry individuals
Region6q16.3
Chromosome idchr6
Chromosome position104960124
Reported geneLIN28B
Mapped geneLIN28B
Upstream gene id
Downstream gene id
SNP gene ids389421
Upstream gene distance
Downstream gene distance
SNP risk allelers314276-C
SNPsrs314276
Merged0
SNP id current314276
Contextintron_variant
Intergenic0
Allele frequency0.66
P value0.00000002
Pvalue mlog7.69897000433601
P value text
Or beta0.08
%95 Ci[0.053-0.107] unit increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitpuberty onset measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005677
Study accessionGCST002425