SNP Detail For rs3097645
1.Mapping Information
Human SNP ID rs3097645
Human chromosome chr6
Human SNP position 32985503
Pig chromosome chr7
Pig SNP position 29531906
2.Annotation Information
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region6p21.32
Chromosome idchr6
Chromosome position32985503
Reported geneNR
Mapped geneBRD2 - HLA-DOA
Upstream gene id6046
Downstream gene id3111
SNP gene ids
Upstream gene distance3998
Downstream gene distance18679
SNP risk allelers3097645-C
SNPsrs3097645
Merged0
SNP id current3097645
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.873857556055831
P value0.000006
Pvalue mlog5.22184874961635
P value text(IGP16)
Or beta0.2057
%95 Ci[0.12-0.29] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region6p21.32
Chromosome idchr6
Chromosome position32985503
Reported geneNR
Mapped geneBRD2 - HLA-DOA
Upstream gene id6046
Downstream gene id3111
SNP gene ids
Upstream gene distance3998
Downstream gene distance18679
SNP risk allelers3097645-C
SNPsrs3097645
Merged0
SNP id current3097645
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.874157767431399
P value0.000005
Pvalue mlog5.30102999566398
P value text(IGP2)
Or beta0.2092
%95 Ci[0.12-0.3] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region6p21.32
Chromosome idchr6
Chromosome position32985503
Reported geneNR
Mapped geneBRD2 - HLA-DOA
Upstream gene id6046
Downstream gene id3111
SNP gene ids
Upstream gene distance3998
Downstream gene distance18679
SNP risk allelers3097645-C
SNPsrs3097645
Merged0
SNP id current3097645
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.874270331235955
P value0.000002
Pvalue mlog5.69897000433601
P value text(IGP42)
Or beta0.2151
%95 Ci[0.13-0.3] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region6p21.32
Chromosome idchr6
Chromosome position32985503
Reported geneNR
Mapped geneBRD2 - HLA-DOA
Upstream gene id6046
Downstream gene id3111
SNP gene ids
Upstream gene distance3998
Downstream gene distance18679
SNP risk allelers3097645-C
SNPsrs3097645
Merged0
SNP id current3097645
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.873514573726542
P value0.000003
Pvalue mlog5.52287874528033
P value text(IGP58)
Or beta0.2131
%95 Ci[0.12-0.3] unit increase
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region6p21.32
Chromosome idchr6
Chromosome position32985503
Reported geneNR
Mapped geneBRD2 - HLA-DOA
Upstream gene id6046
Downstream gene id3111
SNP gene ids
Upstream gene distance3998
Downstream gene distance18679
SNP risk allelers3097645-C
SNPsrs3097645
Merged0
SNP id current3097645
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.87438328769575
P value0.000007
Pvalue mlog5.15490195998574
P value text(IGP59)
Or beta0.2057
%95 Ci[0.12-0.3] unit increase
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region6p21.32
Chromosome idchr6
Chromosome position32985503
Reported geneNR
Mapped geneBRD2 - HLA-DOA
Upstream gene id6046
Downstream gene id3111
SNP gene ids
Upstream gene distance3998
Downstream gene distance18679
SNP risk allelers3097645-C
SNPsrs3097645
Merged0
SNP id current3097645
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.873550828800713
P value0.000006
Pvalue mlog5.22184874961635
P value text(IGP61)
Or beta0.206
%95 Ci[0.12-0.3] unit increase
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region6p21.32
Chromosome idchr6
Chromosome position32985503
Reported geneNR
Mapped geneBRD2 - HLA-DOA
Upstream gene id6046
Downstream gene id3111
SNP gene ids
Upstream gene distance3998
Downstream gene distance18679
SNP risk allelers3097645-C
SNPsrs3097645
Merged0
SNP id current3097645
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.872971129118433
P value0.0000006
Pvalue mlog6.22184874961635
P value text(IGP65)
Or beta0.2253
%95 Ci[0.14-0.31] unit increase
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848