SNP Detail For rs2869966
1.Mapping Information
Human SNP ID rs2869966
Human chromosome chr4
Human SNP position 88947927
Pig chromosome chr8
Pig SNP position 139567125
2.Annotation Information
PubMed ID25241909
JournalRespir Res
Linkwww.ncbi.nlm.nih.gov/pubmed/25241909
StudyGenetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.
Disease/TraitChronic obstructive pulmonary disease
Initial sample3,777 European ancestry cases, 3,520 European ancestry smoker controls
Replication sampleNA
Region4q22.1
Chromosome idchr4
Chromosome position88947927
Reported geneFAM13A
Mapped geneFAM13A, LOC105377327
Upstream gene id
Downstream gene id
SNP gene ids10144, 105377327
Upstream gene distance
Downstream gene distance
SNP risk allelers2869966-T
SNPsrs2869966
Merged0
SNP id current2869966
Contextintron_variant
Intergenic0
Allele frequency0.41
P value0.0000000007
Pvalue mlog9.15490195998574
P value text
Or beta1.29
%95 Ci[1.19-1.40]
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitchronic obstructive pulmonary disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000341
Study accessionGCST002624
PubMed ID26634245
JournalBMC Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26634245
StudyA genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
Disease/TraitPost bronchodilator FEV1
Initial sample10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals
Replication sampleNA
Region4q22.1
Chromosome idchr4
Chromosome position88947927
Reported geneFAM13A
Mapped geneFAM13A, LOC105377327
Upstream gene id
Downstream gene id
SNP gene ids10144, 105377327
Upstream gene distance
Downstream gene distance
SNP risk allelers2869966-T
SNPsrs2869966
Merged0
SNP id current2869966
Contextintron_variant
Intergenic0
Allele frequency0.55
P value0.000000000001
Pvalue mlog12
P value text
Or beta0.062
%95 CiNR unit decrease
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitforced expiratory volume, response to bronchodilator
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004314, http://purl.obolibrary.org/obo/GO_0097366
Study accessionGCST003262
PubMed ID26634245
JournalBMC Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26634245
StudyA genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
Disease/TraitPost bronchodilator FEV1/FVC ratio
Initial sample10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals
Replication sampleNA
Region4q22.1
Chromosome idchr4
Chromosome position88947927
Reported geneFAM13A
Mapped geneFAM13A, LOC105377327
Upstream gene id
Downstream gene id
SNP gene ids10144, 105377327
Upstream gene distance
Downstream gene distance
SNP risk allelers2869966-T
SNPsrs2869966
Merged0
SNP id current2869966
Contextintron_variant
Intergenic0
Allele frequency0.55
P value0.000000000002
Pvalue mlog11.698970004336
P value text
Or beta0.012
%95 Ciunit decrease
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitresponse to bronchodilator, FEV/FEC ratio
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0004713
Study accessionGCST003264