SNP Detail For rs2840044
1.Mapping Information
Human SNP ID rs2840044
Human chromosome chr17
Human SNP position 35565049
Pig chromosome chr12
Pig SNP position 41455009
2.Annotation Information
PubMed ID24785509
JournalRadiother Oncol
Linkwww.ncbi.nlm.nih.gov/pubmed/24785509
StudyA genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity.
Disease/TraitResponse to radiotherapy in cancer (late toxicity)
Initial sample579 European ancestry prostate cancer cases, 1,194 European ancestry breast cancer cases
Replication sample516 European ancestry prostate cancer cases, 862 prostate cancer cases, 355 breast cancer cases
Region17q12
Chromosome idchr17
Chromosome position35565049
Reported geneSLFN14
Mapped geneSLFN14 - RPL39P32
Upstream gene id342618
Downstream gene id100131387
SNP gene ids
Upstream gene distance4213
Downstream gene distance1411
SNP risk allelers2840044-?
SNPsrs2840044
Merged0
SNP id current2840044
Contextupstream_gene_variant
Intergenic1
Allele frequency0.33
P value0.000008
Pvalue mlog5.09691001300805
P value text(Breast cancer, overal toxicity, multivariable analysis)
Or beta1.56
%95 Ci
PlatformIllumina [2417493] (imputed)
CNVN
Mapped traitresponse to radiation, breast carcinoma
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0009314, http://www.ebi.ac.uk/efo/EFO_0000305
Study accessionGCST002431