Human SNP ID | rs28381684 |
---|---|
Human chromosome | chr11 |
Human SNP position | 102866461 |
Pig chromosome | chr9 |
Pig SNP position | 37424498 |
PubMed ID | 26634245 |
---|---|
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Post bronchodilator FEV1 |
Initial sample | 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals |
Replication sample | NA |
Region | 11q22.2 |
Chromosome id | chr11 |
Chromosome position | 102866461 |
Reported gene | MMP12 |
Mapped gene | MMP12 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4321 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs28381684-A |
SNPs | rs28381684 |
Merged | 0 |
SNP id current | 28381684 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.886 |
P value | 0.000001 |
Pvalue mlog | 6 |
P value text | |
Or beta | 0.073 |
%95 Ci | NR unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | forced expiratory volume, response to bronchodilator |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004314, http://purl.obolibrary.org/obo/GO_0097366 |
Study accession | GCST003262 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Post bronchodilator FEV1/FVC ratio in COPD |
Initial sample | 5,439 European ancestry current and former smoker cases, 821 African American current and former smoker cases |
Replication sample | NA |
Region | 11q22.2 |
Chromosome id | chr11 |
Chromosome position | 102866461 |
Reported gene | MMP12 |
Mapped gene | MMP12 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4321 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs28381684-A |
SNPs | rs28381684 |
Merged | 0 |
SNP id current | 28381684 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.89 |
P value | 0.000004 |
Pvalue mlog | 5.39794000867203 |
P value text | |
Or beta | 0.018 |
%95 Ci | NR unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | response to bronchodilator, chronic obstructive pulmonary disease, FEV/FEC ratio |
Mapped trait URI | http://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0000341, http://www.ebi.ac.uk/efo/EFO_0004713 |
Study accession | GCST003265 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Post bronchodilator FEV1/FVC ratio |
Initial sample | 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals |
Replication sample | NA |
Region | 11q22.2 |
Chromosome id | chr11 |
Chromosome position | 102866461 |
Reported gene | MMP12 |
Mapped gene | MMP12 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4321 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs28381684-A |
SNPs | rs28381684 |
Merged | 0 |
SNP id current | 28381684 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.886 |
P value | 0.0000000005 |
Pvalue mlog | 9.30102999566398 |
P value text | |
Or beta | 0.019 |
%95 Ci | unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | response to bronchodilator, FEV/FEC ratio |
Mapped trait URI | http://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0004713 |
Study accession | GCST003264 |