SNP Detail For rs28374715
1.Mapping Information
Human SNP ID rs28374715
Human chromosome chr15
Human SNP position 41271752
Pig chromosome chr1
Pig SNP position 145226701
2.Annotation Information
PubMed ID23128233
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/23128233
StudyHost-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Disease/TraitUlcerative colitis
Initial sampleUp to 12,924 European ancestry cases, up to 21,442 European ancestry controls
Replication sampleUp to 25,683 European ancestry cases, up to 17,015 European ancestry controls
Region15q15.1
Chromosome idchr15
Chromosome position41271752
Reported geneITPKA, NDUFAF1, NUSAP1
Mapped geneCHP1
Upstream gene id
Downstream gene id
SNP gene ids11261
Upstream gene distance
Downstream gene distance
SNP risk allelers28374715-A
SNPsrs28374715
Merged0
SNP id current28374715
Contextintron_variant
Intergenic0
Allele frequency0.738
P value0.00000002
Pvalue mlog7.69897000433601
P value text
Or beta1.082
%95 Ci[1.04-1.126]
PlatformAffymetrix, Illumina [1230000] (imputed)
CNVN
Mapped traitulcerative colitis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000729
Study accessionGCST001728
PubMed ID26192919
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26192919
StudyAssociation analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
Disease/TraitUlcerative colitis
Initial sample6,968 European ancestry cases, 20,464 European ancestry controls
Replication sample10,679 European ancestry cases, 26,715 European ancestry controls, 397 Iranian ancestry cases, 342 Iranian ancestry controls, 1,239 Indian ancestry cases, 990 Indian ancestry controls, 1,134 East Asian ancestry cases, 3,719 East Asian ancestry controls
Region15q15.1
Chromosome idchr15
Chromosome position41271752
Reported geneNR
Mapped geneCHP1
Upstream gene id
Downstream gene id
SNP gene ids11261
Upstream gene distance
Downstream gene distance
SNP risk allelers28374715-A
SNPsrs28374715
Merged0
SNP id current28374715
Contextintron_variant
Intergenic0
Allele frequency0.74
P value0.00000009
Pvalue mlog7.04575749056067
P value text(EA)
Or beta1.0816516
%95 Ci
PlatformAffymetrix, Illumina [~ 9000000] (imputed)
CNVN
Mapped traitulcerative colitis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000729
Study accessionGCST003045