SNP Detail For rs2823286
1.Mapping Information
Human SNP ID rs2823286
Human chromosome chr21
Human SNP position 15445619
Pig chromosome chr13
Pig SNP position 190558608
2.Annotation Information
PubMed ID23128233
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/23128233
StudyHost-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Disease/TraitInflammatory bowel disease
Initial sample12,924 European ancestry cases, 21,442 European ancestry controls
Replication sample25,683 European ancestry cases, 17,015 European ancestry controls
Region21q21.1
Chromosome idchr21
Chromosome position15445619
Reported geneintergenic
Mapped geneLOC101927745 - LOC105369302
Upstream gene id101927745
Downstream gene id105369302
SNP gene ids
Upstream gene distance945
Downstream gene distance125579
SNP risk allelers2823286-G
SNPsrs2823286
Merged0
SNP id current2823286
Contextintron_variant
Intergenic1
Allele frequency0.708
P value9E-30
Pvalue mlog29.0457574905606
P value text
Or beta1.157
%95 Ci[1.121-1.194]
PlatformAffymetrix, Illumina [1230000] (imputed)
CNVN
Mapped traitinflammatory bowel disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003767
Study accessionGCST001725
PubMed ID26192919
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26192919
StudyAssociation analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
Disease/TraitUlcerative colitis
Initial sample6,968 European ancestry cases, 20,464 European ancestry controls
Replication sample10,679 European ancestry cases, 26,715 European ancestry controls, 397 Iranian ancestry cases, 342 Iranian ancestry controls, 1,239 Indian ancestry cases, 990 Indian ancestry controls, 1,134 East Asian ancestry cases, 3,719 East Asian ancestry controls
Region21q21.1
Chromosome idchr21
Chromosome position15445619
Reported geneNR
Mapped geneLOC101927745 - LOC105369302
Upstream gene id101927745
Downstream gene id105369302
SNP gene ids
Upstream gene distance945
Downstream gene distance125579
SNP risk allelers2823286-G
SNPsrs2823286
Merged0
SNP id current2823286
Contextintron_variant
Intergenic1
Allele frequency0.71
P value0.000000000002
Pvalue mlog11.698970004336
P value text(EA)
Or beta1.1033705
%95 Ci
PlatformAffymetrix, Illumina [~ 9000000] (imputed)
CNVN
Mapped traitulcerative colitis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000729
Study accessionGCST003045
PubMed ID26192919
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26192919
StudyAssociation analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
Disease/TraitCrohn__s disease
Initial sample5,956 European ancestry cases, 14,927 European ancestry controls
Replication sample14,594 European ancestry cases, 26,715 European ancestry controls, 151 Iranian ancestry cases, 342 Iranian ancestry controls, 184 Indian ancestry cases, 990 Indian ancestry controls, 1,690 East Asian ancestry cases, 3,719 East Asian ancestry controls
Region21q21.1
Chromosome idchr21
Chromosome position15445619
Reported geneNR
Mapped geneLOC101927745 - LOC105369302
Upstream gene id101927745
Downstream gene id105369302
SNP gene ids
Upstream gene distance945
Downstream gene distance125579
SNP risk allelers2823286-A
SNPsrs2823286
Merged0
SNP id current2823286
Contextintron_variant
Intergenic1
Allele frequency0.71
P value1E-24
Pvalue mlog24
P value text(EA)
Or beta1.1480856
%95 Ci
PlatformAffymetrix, Illumina [~ 9000000] (imputed)
CNVN
Mapped traitCrohn__s disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000384
Study accessionGCST003044