SNP Detail For rs281508
1.Mapping Information
Human SNP ID rs281508
Human chromosome chr2
Human SNP position 46184068
Pig chromosome chr3
Pig SNP position 100431751
2.Annotation Information
PubMed ID26031901
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/26031901
StudyGenome-wide association study of leukotriene modifier response in asthma.
Disease/TraitResponse to zileuton treatment in asthma (FEV1 change interaction)
Initial sample160 European and other ancestry zileuton-treated cases, 144 European and other ancestry placebo-controlled cases
Replication sample149 European and other ancestry zileuton-treated cases, 73 European and other ancestry placebo-controlled cases
Region2p21
Chromosome idchr2
Chromosome position46184068
Reported genePRKCE
Mapped genePRKCE
Upstream gene id
Downstream gene id
SNP gene ids5581
Upstream gene distance
Downstream gene distance
SNP risk allelers281508-?
SNPsrs281508
Merged
SNP id current281508
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.000001
Pvalue mlog6
P value text(Recessive model)
Or beta0.77
%95 Ciunit increase
PlatformIllumina [542562]
CNVN
Mapped traitFEV change measurement, response to zileuton, asthma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005921, http://www.ebi.ac.uk/efo/EFO_0007676, http://www.ebi.ac.uk/efo/EFO_0000270
Study accessionGCST002951