SNP Detail For rs2794520
1.Mapping Information
Human SNP ID rs2794520
Human chromosome chr1
Human SNP position 159709026
Pig chromosome chr4
Pig SNP position 98761390
2.Annotation Information
PubMed ID17903293
JournalBMC Med Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/17903293
StudyGenome-wide association with select biomarker traits in the Framingham Heart Study.
Disease/TraitSelect biomarker traits
Initial sample1,012 European ancestry individuals
Replication sampleNA
Region1q23.2
Chromosome idchr1
Chromosome position159709026
Reported geneCRP
Mapped geneAPCS - CRP
Upstream gene id325
Downstream gene id1401
SNP gene ids
Upstream gene distance120155
Downstream gene distance3263
SNP risk allelers2794520-?
SNPsrs2794520
Merged0
SNP id current2794520
Contextupstream_gene_variant
Intergenic1
Allele frequencyNR
P value0.00000003
Pvalue mlog7.52287874528033
P value text(CRP average 2,6,7)
Or beta
%95 Ci
PlatformAffymetrix [70897]
CNVN
Mapped traitC-reactive protein measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004458
Study accessionGCST000083
PubMed ID19060910
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/19060910
StudyGenome-wide association analysis of metabolic traits in a birth cohort from a founder population.
Disease/TraitMetabolic traits
Initial sample4,763 Northern Finnish founder individuals
Replication sampleNA
Region1q23.2
Chromosome idchr1
Chromosome position159709026
Reported geneCRP
Mapped geneAPCS - CRP
Upstream gene id325
Downstream gene id1401
SNP gene ids
Upstream gene distance120155
Downstream gene distance3263
SNP risk allelers2794520-A
SNPsrs2794520
Merged0
SNP id current2794520
Contextupstream_gene_variant
Intergenic1
Allele frequency0.36
P value3E-22
Pvalue mlog21.5228787452803
P value text(CRP)
Or beta0.47
%95 Ci[0.32-0.62] mmol/l decrease
PlatformIllumina [329091]
CNVN
Mapped traitinflammatory response
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0006954
Study accessionGCST000292
PubMed ID21300955
JournalCirculation
Linkwww.ncbi.nlm.nih.gov/pubmed/21300955
StudyMeta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
Disease/TraitC-reactive protein levels
Initial sample63,678 European ancestry individuals 1,792 Erasmus Ruchpen individuals, 715 Orcadian individuals
Replication sample16,540 European ancestry individuals
Region1q23.2
Chromosome idchr1
Chromosome position159709026
Reported geneCRP
Mapped geneAPCS - CRP
Upstream gene id325
Downstream gene id1401
SNP gene ids
Upstream gene distance120155
Downstream gene distance3263
SNP risk allelers2794520-C
SNPsrs2794520
Merged0
SNP id current2794520
Contextupstream_gene_variant
Intergenic1
Allele frequencyNR
P value2E-186
Pvalue mlog185.698970004336
P value text
Or beta0.16
%95 Ci[0.15-0.17] unit increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitC-reactive protein measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004458
Study accessionGCST000965