SNP Detail For rs27524
1.Mapping Information
Human SNP ID rs27524
Human chromosome chr5
Human SNP position 96766240
Pig chromosome chr2
Pig SNP position 107114872
2.Annotation Information
PubMed ID20953190
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20953190
StudyA genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
Disease/TraitPsoriasis
Initial sample2,178 European ancestry cases, 5,175 European ancestry controls
Replication sample3,174 European ancestry cases, 5,464 European ancestry controls
Region5q15
Chromosome idchr5
Chromosome position96766240
Reported geneERAP1
Mapped geneERAP1, CAST
Upstream gene id
Downstream gene id
SNP gene ids51752, 831
Upstream gene distance
Downstream gene distance
SNP risk allelers27524-A
SNPsrs27524
Merged0
SNP id current27524
Contextintron_variant
Intergenic0
Allele frequency0.36
P value0.00000000003
Pvalue mlog10.5228787452803
P value text
Or beta1.13
%95 Ci[1.05-1.22]
PlatformIllumina [535475]
CNVN
Mapped traitpsoriasis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000676
Study accessionGCST000833
PubMed ID22286212
JournalJ Natl Cancer Inst
Linkwww.ncbi.nlm.nih.gov/pubmed/22286212
StudyGenome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups.
Disease/TraitHodgkin__s lymphoma
Initial sample1,200 European ancestry cases, 6,417 European ancestry controls
Replication sample563 European ancestry cases, 613 European ancestry controls
Region5q15
Chromosome idchr5
Chromosome position96766240
Reported geneERAP1
Mapped geneERAP1, CAST
Upstream gene id
Downstream gene id
SNP gene ids51752, 831
Upstream gene distance
Downstream gene distance
SNP risk allelers27524-?
SNPsrs27524
Merged0
SNP id current27524
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.000007
Pvalue mlog5.15490195998574
P value text(Total cHL)
Or beta1.22
%95 Ci[1.11-1.33]
PlatformIllumina [502514]
CNVN
Mapped traitHodgkins lymphoma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000183
Study accessionGCST001387
PubMed ID25574825
JournalAm J Hum Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25574825
StudyGenome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
Disease/TraitPsoriasis
Initial sample4,212 European ancestry cases, 8,032 European ancestry controls
Replication sampleNA
Region5q15
Chromosome idchr5
Chromosome position96766240
Reported geneERAP1
Mapped geneERAP1, CAST
Upstream gene id
Downstream gene id
SNP gene ids51752, 831
Upstream gene distance
Downstream gene distance
SNP risk allelers27524-A
SNPsrs27524
Merged0
SNP id current27524
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.00000002
Pvalue mlog7.69897000433601
P value text
Or beta1.195
%95 Ci[1.157-1.234]
PlatformAffymetrix, Illumina, Perlegen [up to 5493100] (imputed)
CNVN
Mapped traitpsoriasis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000676
Study accessionGCST002738