SNP Detail For rs273259
1.Mapping Information
Human SNP ID rs273259
Human chromosome chr1
Human SNP position 78628133
Pig chromosome chr6
Pig SNP position 124828969
2.Annotation Information
PubMed ID25344690
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25344690
StudyCommon variants associated with general and MMR vaccine-related febrile seizures.
Disease/TraitFebrile seizures
Initial sample929 European ancestry MMR vaccine-related febrile seizures cases, 1,070 European ancestry MMR vaccine-unrelated febrile seizures cases, 4,118 European ancestry controls
Replication sampleUp to 408 European ancestry MMR vaccine-related febrile seizures cases, Up to 1,034 European ancestry MMR vaccine-unrelated febrile seizures cases, Up to 1,645 European ancestry controls
Region1p31.1
Chromosome idchr1
Chromosome position78628133
Reported geneIFI44L
Mapped geneIFI44L
Upstream gene id
Downstream gene id
SNP gene ids10964
Upstream gene distance
Downstream gene distance
SNP risk allelers273259-A
SNPsrs273259
Merged0
SNP id current273259
Contextmissense_variant
Intergenic0
Allele frequency0.694
P value0.000000001
Pvalue mlog9
P value text(MMR-related vs MMR-unrelated)
Or beta1.42
%95 Ci[1.27-1.59]
PlatformIllumina [up to 8129553] (imputed)
CNVN
Mapped traitfebrile seizures, MMR-related febrile seizures
Mapped trait URIhttp://purl.obolibrary.org/obo/HP_0002373, http://www.ebi.ac.uk/efo/EFO_0006519
Study accessionGCST002672
PubMed ID25344690
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25344690
StudyCommon variants associated with general and MMR vaccine-related febrile seizures.
Disease/TraitFebrile seizures (MMR vaccine-related)
Initial sample929 European ancestry cases, 4,118 European ancestry controls
Replication sampleUp to 408 European ancestry cases, Up to 1,645 European ancestry controls
Region1p31.1
Chromosome idchr1
Chromosome position78628133
Reported geneIFI44L
Mapped geneIFI44L
Upstream gene id
Downstream gene id
SNP gene ids10964
Upstream gene distance
Downstream gene distance
SNP risk allelers273259-A
SNPsrs273259
Merged0
SNP id current273259
Contextmissense_variant
Intergenic0
Allele frequency0.702
P value0.000000000006
Pvalue mlog11.2218487496163
P value text
Or beta1.41
%95 Ci[1.28-1.55]
PlatformIllumina [8129524] (imputed)
CNVN
Mapped traitMMR-related febrile seizures
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006519
Study accessionGCST002674