SNP Detail For rs2727270
1.Mapping Information
Human SNP ID rs2727270
Human chromosome chr11
Human SNP position 61835765
Pig chromosome chr2
Pig SNP position 9126837
2.Annotation Information
PubMed ID24823311
JournalCirc Cardiovasc Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24823311
StudyGenome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
Disease/TraitPlasma omega-6 polyunsaturated fatty acid levels (linoleic acid)
Initial sample8,631 European ancestry individuals
Replication sampleNA
Region11q12.2
Chromosome idchr11
Chromosome position61835765
Reported geneFTH1, INCENP, FADS1, FADS2, SCGB1D1, SCGB2A1, C11orf9, DAGLA, FEN1, RAB3IL, C11orf10, FADS3, SYT7, BEST1, SCGB1D2
Mapped geneFADS2
Upstream gene id
Downstream gene id
SNP gene ids9415
Upstream gene distance
Downstream gene distance
SNP risk allelers2727270-T
SNPsrs2727270
Merged0
SNP id current2727270
Contextintron_variant
Intergenic0
Allele frequency0.44
P value3E-21
Pvalue mlog20.5228787452803
P value text(Conditioned on rs174547)
Or beta0.69
%95 Ci[0.55-0.83] unit increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitomega-6 polyunsaturated fatty acid measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005680
Study accessionGCST002446
PubMed ID25646338
JournalAm J Clin Nutr
Linkwww.ncbi.nlm.nih.gov/pubmed/25646338
StudyGenetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
Disease/TraitTrans fatty acid levels
Initial sample8,013 European ancestry individuals
Replication sample1,082 African American individuals, 669 Chinese ancestry individuals, 657 Hispanic individuals
Region11q12.2
Chromosome idchr11
Chromosome position61835765
Reported geneNR
Mapped geneFADS2
Upstream gene id
Downstream gene id
SNP gene ids9415
Upstream gene distance
Downstream gene distance
SNP risk allelers2727270-T
SNPsrs2727270
Merged0
SNP id current2727270
Contextintron_variant
Intergenic0
Allele frequency0.1209
P value0.000000007
Pvalue mlog8.15490195998574
P value text(Cis/trans-18:2, EA)
Or beta0.0038
%95 Ci[0.0026-0.005] unit increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitcis/trans-18:2 fatty acid measurement, trans fatty acid measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006824, http://www.ebi.ac.uk/efo/EFO_0006821
Study accessionGCST002721