SNP Detail For rs2720499
1.Mapping Information
Human SNP ID rs2720499
Human chromosome chr8
Human SNP position 17534848
Pig chromosome chr17
Pig SNP position 5696236
2.Annotation Information
PubMed ID26031901
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/26031901
StudyGenome-wide association study of leukotriene modifier response in asthma.
Disease/TraitResponse to zileuton treatment in asthma (FEV1 change interaction)
Initial sample160 European and other ancestry zileuton-treated cases, 144 European and other ancestry placebo-controlled cases
Replication sample149 European and other ancestry zileuton-treated cases, 73 European and other ancestry placebo-controlled cases
Region8p22
Chromosome idchr8
Chromosome position17534848
Reported geneSLC7A2
Mapped geneSLC7A2
Upstream gene id
Downstream gene id
SNP gene ids6542
Upstream gene distance
Downstream gene distance
SNP risk allelers2720499-?
SNPsrs2720499
Merged
SNP id current2720499
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.0000003
Pvalue mlog6.52287874528033
P value text(Recessive model)
Or beta2.42
%95 Ciunit decrease
PlatformIllumina [542562]
CNVN
Mapped traitFEV change measurement, response to zileuton, asthma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005921, http://www.ebi.ac.uk/efo/EFO_0007676, http://www.ebi.ac.uk/efo/EFO_0000270
Study accessionGCST002951