Human SNP ID | rs2686586 |
---|---|
Human chromosome | chr3 |
Human SNP position | 168180033 |
Pig chromosome | chr13 |
Pig SNP position | 115444111 |
PubMed ID | 23400010 |
---|---|
Journal | Pharmacogenomics J |
Link | www.ncbi.nlm.nih.gov/pubmed/23400010 |
Study | Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. |
Disease/Trait | Thiazide-induced adverse metabolic effects in hypertensive patients |
Initial sample | 425 European ancestry cases, 342 African American cases |
Replication sample | NA |
Region | 3q26.2 |
Chromosome id | chr3 |
Chromosome position | 168180033 |
Reported gene | GOLIM4 |
Mapped gene | GOLIM4 - EGFEM1P |
Upstream gene id | 27333 |
Downstream gene id | 93556 |
SNP gene ids | |
Upstream gene distance | 84109 |
Downstream gene distance | 69489 |
SNP risk allele | rs2686586-T |
SNPs | rs2686586 |
Merged | 0 |
SNP id current | 2686586 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | 0.47 |
P value | 0.00000006 |
Pvalue mlog | 7.22184874961635 |
P value text | (AA-triglyceride response) |
Or beta | 18.93 |
%95 Ci | [11.89-25.97] mg/dL increase |
Platform | Affymetrix, Illumina [> 2000000] (imputed) |
CNV | N |
Mapped trait | response to hydrochlorothiazide, triglyceride measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005202, http://www.ebi.ac.uk/efo/EFO_0004530 |
Study accession | GCST001859 |