SNP Detail For rs2686586
1.Mapping Information
Human SNP ID rs2686586
Human chromosome chr3
Human SNP position 168180033
Pig chromosome chr13
Pig SNP position 115444111
2.Annotation Information
PubMed ID23400010
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/23400010
StudyGenome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
Disease/TraitThiazide-induced adverse metabolic effects in hypertensive patients
Initial sample425 European ancestry cases, 342 African American cases
Replication sampleNA
Region3q26.2
Chromosome idchr3
Chromosome position168180033
Reported geneGOLIM4
Mapped geneGOLIM4 - EGFEM1P
Upstream gene id27333
Downstream gene id93556
SNP gene ids
Upstream gene distance84109
Downstream gene distance69489
SNP risk allelers2686586-T
SNPsrs2686586
Merged0
SNP id current2686586
Contextintergenic_variant
Intergenic1
Allele frequency0.47
P value0.00000006
Pvalue mlog7.22184874961635
P value text(AA-triglyceride response)
Or beta18.93
%95 Ci[11.89-25.97] mg/dL increase
PlatformAffymetrix, Illumina [> 2000000] (imputed)
CNVN
Mapped traitresponse to hydrochlorothiazide, triglyceride measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005202, http://www.ebi.ac.uk/efo/EFO_0004530
Study accessionGCST001859