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SNP Detail For rs2568958
1.Mapping Information
| Human SNP ID | rs2568958 |
|---|---|
| Human chromosome | chr1 |
| Human SNP position | 72299433 |
| Pig chromosome | chr6 |
| Pig SNP position | 130091579 |
2.Annotation Information
| PubMed ID | 23563607 |
|---|---|
| Journal | Nat Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/23563607 |
| Study | Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. |
| Disease/Trait | Obesity |
| Initial sample | 93,015 European ancestry overweight individuals, 32,858 European ancestry class I obese individuals, 9,889 European ancestry class II obese individuals, 2,896 European ancestry class III obese individuals, up to 65,840 European ancestry controls |
| Replication sample | 65,332 European ancestry overweight individuals, 22,373 European ancestry class I obese individuals, 5,476 European ancestry class II obese individuals, 1,162 European ancestry class III obese individuals, up to 39,294 European ancestry controls |
| Region | 1p31.1 |
| Chromosome id | chr1 |
| Chromosome position | 72299433 |
| Reported gene | NEGR1 |
| Mapped gene | LOC105378797 |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 105378797 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs2568958-A |
| SNPs | rs2568958 |
| Merged | 0 |
| SNP id current | 2568958 |
| Context | upstream_gene_variant |
| Intergenic | 0 |
| Allele frequency | 0.61 |
| P value | 0.0000000000000004 |
| Pvalue mlog | 15.397940008672 |
| P value text | (Overweight) |
| Or beta | 1.06 |
| %95 Ci | [NR] |
| Platform | Affymetrix, Illumina [~ 2800000] (imputed) |
| CNV | N |
| Mapped trait | obesity |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0001073 |
| Study accession | GCST001953 |
| PubMed ID | 23563607 |
| Journal | Nat Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/23563607 |
| Study | Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. |
| Disease/Trait | Body mass index |
| Initial sample | 7,962 European ancestry high body mass index individuals, 8,106 European ancestry low body mass index individuals |
| Replication sample | 4,900 European ancestry high body mass index individuals, 4,891 European ancestry low body mass index individuals |
| Region | 1p31.1 |
| Chromosome id | chr1 |
| Chromosome position | 72299433 |
| Reported gene | NEGR1 |
| Mapped gene | LOC105378797 |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 105378797 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs2568958-A |
| SNPs | rs2568958 |
| Merged | 0 |
| SNP id current | 2568958 |
| Context | upstream_gene_variant |
| Intergenic | 0 |
| Allele frequency | 0.6 |
| P value | 0.00000000000002 |
| Pvalue mlog | 13.698970004336 |
| P value text | |
| Or beta | 1.16 |
| %95 Ci | [NR] |
| Platform | Affymetrix, Illumina [~ 2800000] (imputed) |
| CNV | N |
| Mapped trait | body mass index |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004340 |
| Study accession | GCST001955 |
| PubMed ID | 19079260 |
| Journal | Nat Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/19079260 |
| Study | Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. |
| Disease/Trait | Weight |
| Initial sample | 72,598 European ancestry individuals, 1,160 African American individuals |
| Replication sample | Up to 11,036 European ancestry individuals, 32,615 individuals |
| Region | 1p31.1 |
| Chromosome id | chr1 |
| Chromosome position | 72299433 |
| Reported gene | NEGR1 |
| Mapped gene | LOC105378797 |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 105378797 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs2568958-A |
| SNPs | rs2568958 |
| Merged | 0 |
| SNP id current | 2568958 |
| Context | upstream_gene_variant |
| Intergenic | 0 |
| Allele frequency | 0.58 |
| P value | 0.00000002 |
| Pvalue mlog | 7.69897000433601 |
| P value text | |
| Or beta | 3.37 |
| %95 Ci | [2.19-4.55] percentage SD increase |
| Platform | Illumina [305846] |
| CNV | N |
| Mapped trait | body weight |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004338 |
| Study accession | GCST000299 |
| PubMed ID | 19079260 |
| Journal | Nat Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/19079260 |
| Study | Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. |
| Disease/Trait | Body mass index |
| Initial sample | 72,598 European ancestry individuals, 1,160 African American individuals |
| Replication sample | Up to 11,036 European ancestry individuals, 32,615 individuals |
| Region | 1p31.1 |
| Chromosome id | chr1 |
| Chromosome position | 72299433 |
| Reported gene | NEGR1 |
| Mapped gene | LOC105378797 |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 105378797 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs2568958-A |
| SNPs | rs2568958 |
| Merged | 0 |
| SNP id current | 2568958 |
| Context | upstream_gene_variant |
| Intergenic | 0 |
| Allele frequency | 0.58 |
| P value | 0.00000000001 |
| Pvalue mlog | 11 |
| P value text | |
| Or beta | 3.77 |
| %95 Ci | [2.67-4.87] % SD increase |
| Platform | Illumina [305846] |
| CNV | N |
| Mapped trait | body mass index |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004340 |
| Study accession | GCST000296 |
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