SNP Detail For rs2496589
1.Mapping Information
Human SNP ID rs2496589
Human chromosome chr6
Human SNP position 143412439
Pig chromosome chr1
Pig SNP position 24226113
2.Annotation Information
PubMed ID25117820
JournalBr J Cancer
Linkwww.ncbi.nlm.nih.gov/pubmed/25117820
StudyGenetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100.
Disease/TraitResponse to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab)
Initial sample255 European ancestry cases, 387 European ancestry controls
Replication sample
Region6q24.2
Chromosome idchr6
Chromosome position143412439
Reported geneintergenic
Mapped geneLOC100131471 - ADAT2
Upstream gene id100131471
Downstream gene id134637
SNP gene ids
Upstream gene distance68862
Downstream gene distance10393
SNP risk allelers2496589-?
SNPsrs2496589
Merged0
SNP id current2496589
Contextintergenic_variant
Intergenic1
Allele frequencyNR
P value0.000005
Pvalue mlog5.30102999566398
P value text
Or beta1.7
%95 Ci[NR]
PlatformIllumina [up to 810372] (imputed)
CNVN
Mapped traitcumulative dose response to bevacizumab, breast carcinoma, chemotherapy-induced hypertension
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005944, http://www.ebi.ac.uk/efo/EFO_0000305, http://www.ebi.ac.uk/efo/EFO_0005942
Study accessionGCST002566