Human SNP ID | rs2496589 |
---|---|
Human chromosome | chr6 |
Human SNP position | 143412439 |
Pig chromosome | chr1 |
Pig SNP position | 24226113 |
PubMed ID | 25117820 |
---|---|
Journal | Br J Cancer |
Link | www.ncbi.nlm.nih.gov/pubmed/25117820 |
Study | Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. |
Disease/Trait | Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) |
Initial sample | 255 European ancestry cases, 387 European ancestry controls |
Replication sample | |
Region | 6q24.2 |
Chromosome id | chr6 |
Chromosome position | 143412439 |
Reported gene | intergenic |
Mapped gene | LOC100131471 - ADAT2 |
Upstream gene id | 100131471 |
Downstream gene id | 134637 |
SNP gene ids | |
Upstream gene distance | 68862 |
Downstream gene distance | 10393 |
SNP risk allele | rs2496589-? |
SNPs | rs2496589 |
Merged | 0 |
SNP id current | 2496589 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | NR |
P value | 0.000005 |
Pvalue mlog | 5.30102999566398 |
P value text | |
Or beta | 1.7 |
%95 Ci | [NR] |
Platform | Illumina [up to 810372] (imputed) |
CNV | N |
Mapped trait | cumulative dose response to bevacizumab, breast carcinoma, chemotherapy-induced hypertension |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005944, http://www.ebi.ac.uk/efo/EFO_0000305, http://www.ebi.ac.uk/efo/EFO_0005942 |
Study accession | GCST002566 |