Human SNP ID | rs2470893 |
---|---|
Human chromosome | chr15 |
Human SNP position | 74727108 |
Pig chromosome | chr7 |
Pig SNP position | 63489931 |
PubMed ID | 21876539 |
---|---|
Journal | Mol Psychiatry |
Link | www.ncbi.nlm.nih.gov/pubmed/21876539 |
Study | Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. |
Disease/Trait | Coffee consumption |
Initial sample | 18,176 European ancestry individuals |
Replication sample | 7,929 European ancestry individuals |
Region | 15q24.1 |
Chromosome id | chr15 |
Chromosome position | 74727108 |
Reported gene | CYP1A1, CYP1A2 |
Mapped gene | CYP1A1 - CYP1A2 |
Upstream gene id | 1543 |
Downstream gene id | 1544 |
SNP gene ids | |
Upstream gene distance | 1498 |
Downstream gene distance | 21735 |
SNP risk allele | rs2470893-T |
SNPs | rs2470893 |
Merged | 0 |
SNP id current | 2470893 |
Context | upstream_gene_variant |
Intergenic | 1 |
Allele frequency | NR |
P value | 0.00000000002 |
Pvalue mlog | 10.698970004336 |
P value text | |
Or beta | 0.0675 |
%95 Ci | [0.05-0.09] unit increase |
Platform | Affymetrix, Illumina, Perlegen [~ 2600000] (imputed) |
CNV | N |
Mapped trait | coffee consumption |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004330 |
Study accession | GCST001215 |
PubMed ID | 21490707 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/21490707 |
Study | Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. |
Disease/Trait | Caffeine consumption |
Initial sample | 47,431 European ancestry individuals |
Replication sample | NA |
Region | 15q24.1 |
Chromosome id | chr15 |
Chromosome position | 74727108 |
Reported gene | EDC3, CYP1A1, CYP1A2, LMAN1L, CSK |
Mapped gene | CYP1A1 - CYP1A2 |
Upstream gene id | 1543 |
Downstream gene id | 1544 |
SNP gene ids | |
Upstream gene distance | 1498 |
Downstream gene distance | 21735 |
SNP risk allele | rs2470893-T |
SNPs | rs2470893 |
Merged | 0 |
SNP id current | 2470893 |
Context | upstream_gene_variant |
Intergenic | 1 |
Allele frequency | 0.31 |
P value | 0.00000000000005 |
Pvalue mlog | 13.3010299956639 |
P value text | |
Or beta | 0.12 |
%95 Ci | [0.08-0.16] mg/day increase |
Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | coffee consumption |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004330 |
Study accession | GCST001032 |
PubMed ID | 25288136 |
Journal | Mol Psychiatry |
Link | www.ncbi.nlm.nih.gov/pubmed/25288136 |
Study | Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. |
Disease/Trait | Coffee consumption |
Initial sample | 17,479 European ancestry high consumption individuals, 31,049 European ancestry no or low consumption individuals |
Replication sample | 6,497 European ancestry high consumption individuals, 432 African American high consumption individuals, 6,972 European ancestry no or low consumption individuals, 3,413 African American no or low consumption individuals |
Region | 15q24.1 |
Chromosome id | chr15 |
Chromosome position | 74727108 |
Reported gene | CYP1A1, CYP1A2 |
Mapped gene | CYP1A1 - CYP1A2 |
Upstream gene id | 1543 |
Downstream gene id | 1544 |
SNP gene ids | |
Upstream gene distance | 1498 |
Downstream gene distance | 21735 |
SNP risk allele | rs2470893-T |
SNPs | rs2470893 |
Merged | 0 |
SNP id current | 2470893 |
Context | upstream_gene_variant |
Intergenic | 1 |
Allele frequency | 0.31 |
P value | 5E-19 |
Pvalue mlog | 18.3010299956639 |
P value text | |
Or beta | 0.2 |
%95 Ci | [0.16-0.24] unit increase |
Platform | Affymetrix, Illumina [2376205] (imputed) |
CNV | N |
Mapped trait | coffee consumption |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004330 |
Study accession | GCST002651 |