Human SNP ID | rs240993 |
---|---|
Human chromosome | chr6 |
Human SNP position | 111352511 |
Pig chromosome | chr1 |
Pig SNP position | 86579812 |
PubMed ID | 20953190 |
---|---|
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/20953190 |
Study | A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. |
Disease/Trait | Psoriasis |
Initial sample | 2,178 European ancestry cases, 5,175 European ancestry controls |
Replication sample | 3,174 European ancestry cases, 5,464 European ancestry controls |
Region | 6q21 |
Chromosome id | chr6 |
Chromosome position | 111352511 |
Reported gene | TRAF3IP2 |
Mapped gene | REV3L |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 5980 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs240993-A |
SNPs | rs240993 |
Merged | 0 |
SNP id current | 240993 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.25 |
P value | 5E-20 |
Pvalue mlog | 19.3010299956639 |
P value text | |
Or beta | 1.25 |
%95 Ci | [1.16-1.34] |
Platform | Illumina [535475] |
CNV | N |
Mapped trait | psoriasis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000676 |
Study accession | GCST000833 |
PubMed ID | 25574825 |
Journal | Am J Hum Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/25574825 |
Study | Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms. |
Disease/Trait | Psoriasis |
Initial sample | 4,212 European ancestry cases, 8,032 European ancestry controls |
Replication sample | NA |
Region | 6q21 |
Chromosome id | chr6 |
Chromosome position | 111352511 |
Reported gene | TRAF3IP2 |
Mapped gene | REV3L |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 5980 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs240993-T |
SNPs | rs240993 |
Merged | 0 |
SNP id current | 240993 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.00000000000001 |
Pvalue mlog | 14 |
P value text | |
Or beta | 1.282 |
%95 Ci | [1.241-1.324] |
Platform | Affymetrix, Illumina, Perlegen [up to 5493100] (imputed) |
CNV | N |
Mapped trait | psoriasis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000676 |
Study accession | GCST002738 |
PubMed ID | 25574825 |
Journal | Am J Hum Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/25574825 |
Study | Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms. |
Disease/Trait | Inflammatory skin disease |
Initial sample | 2,079 European ancestry atopic dermatitis cases, 4,212 European ancestry psoriasis cases, 11,899 European ancestry controls |
Replication sample | NA |
Region | 6q21 |
Chromosome id | chr6 |
Chromosome position | 111352511 |
Reported gene | REV3L |
Mapped gene | REV3L |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 5980 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs240993-? |
SNPs | rs240993 |
Merged | 0 |
SNP id current | 240993 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.000000000000000006 |
Pvalue mlog | 17.2218487496163 |
P value text | (Psoriasis) |
Or beta | |
%95 Ci | |
Platform | Affymetrix, Illumina [~ 5200000] |
CNV | N |
Mapped trait | psoriasis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000676 |
Study accession | GCST002740 |
PubMed ID | 25903422 |
Journal | Nat Commun |
Link | www.ncbi.nlm.nih.gov/pubmed/25903422 |
Study | Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. |
Disease/Trait | Psoriasis |
Initial sample | 3,496 European ancestry cases, 5,186 European ancestry controls, 1,588 Chinese ancestry cases, 3,546 Chinese ancestry controls |
Replication sample | 5,134 European ancestry cases, 5,633 European ancestry controls, 5,151 Chinese ancestry cases, 5,152 Chinese ancestry controls |
Region | 6q21 |
Chromosome id | chr6 |
Chromosome position | 111352511 |
Reported gene | TRAF3IP2 |
Mapped gene | REV3L |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 5980 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs240993-T |
SNPs | rs240993 |
Merged | 0 |
SNP id current | 240993 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.26876 |
P value | 0.00000001 |
Pvalue mlog | 8 |
P value text | (EA) |
Or beta | 1.2 |
%95 Ci | [1.15-1.26] |
Platform | Illumina [up to 4778154] (imputed) |
CNV | N |
Mapped trait | psoriasis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000676 |
Study accession | GCST002874 |
PubMed ID | 25903422 |
Journal | Nat Commun |
Link | www.ncbi.nlm.nih.gov/pubmed/25903422 |
Study | Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. |
Disease/Trait | Psoriasis |
Initial sample | 3,496 European ancestry cases, 5,186 European ancestry controls, 1,588 Chinese ancestry cases, 3,546 Chinese ancestry controls |
Replication sample | 5,134 European ancestry cases, 5,633 European ancestry controls, 5,151 Chinese ancestry cases, 5,152 Chinese ancestry controls |
Region | 6q21 |
Chromosome id | chr6 |
Chromosome position | 111352511 |
Reported gene | TRAF3IP2 |
Mapped gene | REV3L |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 5980 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs240993-T |
SNPs | rs240993 |
Merged | 0 |
SNP id current | 240993 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.26876 |
P value | 0.0000009 |
Pvalue mlog | 6.04575749056067 |
P value text | |
Or beta | 1.15 |
%95 Ci | [1.09-1.22] |
Platform | Illumina [up to 4778154] (imputed) |
CNV | N |
Mapped trait | psoriasis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000676 |
Study accession | GCST002874 |