SNP Detail For rs2276109
1.Mapping Information
Human SNP ID rs2276109
Human chromosome chr11
Human SNP position 102875061
Pig chromosome chr9
Pig SNP position 37431303
2.Annotation Information
PubMed ID26634245
JournalBMC Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26634245
StudyA genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
Disease/TraitPost bronchodilator FEV1
Initial sample10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals
Replication sampleNA
Region11q22.2
Chromosome idchr11
Chromosome position102875061
Reported geneIntergenic
Mapped geneMMP12 - BOLA3P1
Upstream gene id4321
Downstream gene id100288111
SNP gene ids
Upstream gene distance27
Downstream gene distance5423
SNP risk allelers2276109-T
SNPsrs2276109
Merged0
SNP id current2276109
Contextupstream_gene_variant
Intergenic1
Allele frequency0.887
P value0.000001
Pvalue mlog6
P value text
Or beta0.072
%95 CiNR unit decrease
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitforced expiratory volume, response to bronchodilator
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004314, http://purl.obolibrary.org/obo/GO_0097366
Study accessionGCST003262
PubMed ID26634245
JournalBMC Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26634245
StudyA genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
Disease/TraitPost bronchodilator FEV1/FVC ratio
Initial sample10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals
Replication sampleNA
Region11q22.2
Chromosome idchr11
Chromosome position102875061
Reported geneIntergenic
Mapped geneMMP12 - BOLA3P1
Upstream gene id4321
Downstream gene id100288111
SNP gene ids
Upstream gene distance27
Downstream gene distance5423
SNP risk allelers2276109-T
SNPsrs2276109
Merged0
SNP id current2276109
Contextupstream_gene_variant
Intergenic1
Allele frequency0.887
P value0.0000000007
Pvalue mlog9.15490195998574
P value text
Or beta0.019
%95 Ciunit decrease
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitresponse to bronchodilator, FEV/FEC ratio
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0004713
Study accessionGCST003264