SNP Detail For rs2274223
1.Mapping Information
Human SNP ID rs2274223
Human chromosome chr10
Human SNP position 94306584
Pig chromosome chr14
Pig SNP position 115594086
2.Annotation Information
PubMed ID21642993
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21642993
StudyGenome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
Disease/TraitEsophageal cancer
Initial sample2,031 Han Chinese ancestry cases, 2,044 Han Chinese ancestry controls
Replication sample3,986 Han Chinese ancestry cases, 4,157 Han Chinese ancestry controls
Region10q23.33
Chromosome idchr10
Chromosome position94306584
Reported genePLCE1
Mapped genePLCE1
Upstream gene id
Downstream gene id
SNP gene ids51196
Upstream gene distance
Downstream gene distance
SNP risk allelers2274223-G
SNPsrs2274223
Merged0
SNP id current2274223
Contextmissense_variant
Intergenic0
Allele frequency0.21
P value4E-20
Pvalue mlog19.397940008672
P value text
Or beta1.34
%95 Ci[1.26-1.42]
PlatformAffymetrix [666141]
CNVN
Mapped traitesophageal carcinoma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0002916
Study accessionGCST001089
PubMed ID25129146
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25129146
StudyJoint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
Disease/TraitEsophageal squamous cell carcinoma
Initial sample5,337 Han Chinese ancestry cases, 5,787 Han Chinese ancestry controls
Replication sample9,654 Han Chinese ancestry cases, 10,058 Han Chinese ancestry controls
Region10q23.33
Chromosome idchr10
Chromosome position94306584
Reported genePLCE1, KIAA1516
Mapped genePLCE1
Upstream gene id
Downstream gene id
SNP gene ids51196
Upstream gene distance
Downstream gene distance
SNP risk allelers2274223-G
SNPsrs2274223
Merged0
SNP id current2274223
Contextmissense_variant
Intergenic0
Allele frequency0.209
P value0.000000000000000004
Pvalue mlog17.397940008672
P value text
Or beta1.35
%95 Ci[1.26-1.45]
PlatformAffymetrix, Illumina [7556215] (imputed)
CNVN
Mapped traitesophageal squamous cell carcinoma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005922
Study accessionGCST002568