SNP Detail For rs2233434
1.Mapping Information
Human SNP ID rs2233434
Human chromosome chr6
Human SNP position 44265183
Pig chromosome chr7
Pig SNP position 45132408
2.Annotation Information
PubMed ID22446963
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22446963
StudyMeta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
Disease/TraitRheumatoid arthritis
Initial sample4,074 Japanese ancestry cases, 16,891 Japanese ancestry controls
Replication sample5,277 Japanese ancestry cases, 21,684 Japanese ancestry controls
Region6p21.1
Chromosome idchr6
Chromosome position44265183
Reported geneNFKBIE
Mapped geneNFKBIE
Upstream gene id
Downstream gene id
SNP gene ids4794
Upstream gene distance
Downstream gene distance
SNP risk allelers2233434-G
SNPsrs2233434
Merged0
SNP id current2233434
Contextmissense_variant
Intergenic0
Allele frequency0.21
P value6E-19
Pvalue mlog18.2218487496163
P value text
Or beta1.19
%95 Ci[1.15-1.24]
PlatformAffymetrix, Illumina [1948139]
CNVN
Mapped traitrheumatoid arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685
Study accessionGCST001454
PubMed ID23028356
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23028356
StudyFunctional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese.
Disease/TraitRheumatoid arthritis
Initial sample2,303 Japanese ancestry cases, 3,380 Japanese ancestry controls
Replication sample5,604 Japanese ancestry cases, 31,982 Japanese ancestry controls
Region6p21.1
Chromosome idchr6
Chromosome position44265183
Reported geneNFKBIE
Mapped geneNFKBIE
Upstream gene id
Downstream gene id
SNP gene ids4794
Upstream gene distance
Downstream gene distance
SNP risk allelers2233434-G
SNPsrs2233434
Merged0
SNP id current2233434
Contextmissense_variant
Intergenic0
Allele frequency0.215
P value0.000000000000001
Pvalue mlog15
P value text
Or beta1.2
%95 Ci[1.15-1.26]
PlatformIllumina [NR]
CNVN
Mapped traitrheumatoid arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685
Study accessionGCST001681