SNP Detail For rs2206277
1.Mapping Information
Human SNP ID rs2206277
Human chromosome chr6
Human SNP position 50830813
Pig chromosome JH118430-1
Pig SNP position 232707
2.Annotation Information
PubMed ID21386085
JournalDiabetes
Linkwww.ncbi.nlm.nih.gov/pubmed/21386085
StudyA bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
Disease/TraitMetabolic syndrome (bivariate traits)
Initial sample22,161 European ancestry individuals
Replication sampleNA
Region6p12.3
Chromosome idchr6
Chromosome position50830813
Reported geneTFAP2B
Mapped geneTFAP2B
Upstream gene id
Downstream gene id
SNP gene ids7021
Upstream gene distance
Downstream gene distance
SNP risk allelers2206277-A
SNPsrs2206277
Merged0
SNP id current2206277
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.0000001
Pvalue mlog7
P value text(WC-GLUC)
Or beta0.17
%95 Ci[0.11-0.23] unit increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitmetabolic syndrome
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000195
Study accessionGCST001007
PubMed ID23563607
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23563607
StudyGenome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Disease/TraitObesity
Initial sample93,015 European ancestry overweight individuals, 32,858 European ancestry class I obese individuals, 9,889 European ancestry class II obese individuals, 2,896 European ancestry class III obese individuals, up to 65,840 European ancestry controls
Replication sample65,332 European ancestry overweight individuals, 22,373 European ancestry class I obese individuals, 5,476 European ancestry class II obese individuals, 1,162 European ancestry class III obese individuals, up to 39,294 European ancestry controls
Region6p12.3
Chromosome idchr6
Chromosome position50830813
Reported geneTFAP2B
Mapped geneTFAP2B
Upstream gene id
Downstream gene id
SNP gene ids7021
Upstream gene distance
Downstream gene distance
SNP risk allelers2206277-T
SNPsrs2206277
Merged0
SNP id current2206277
Contextintron_variant
Intergenic0
Allele frequency0.18
P value0.0000000000000007
Pvalue mlog15.1549019599857
P value text(Overweight)
Or beta1.07
%95 Ci[NR]
PlatformAffymetrix, Illumina [~ 2800000] (imputed)
CNVN
Mapped traitobesity
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001073
Study accessionGCST001953
PubMed ID23563607
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23563607
StudyGenome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Disease/TraitObesity
Initial sample93,015 European ancestry overweight individuals, 32,858 European ancestry class I obese individuals, 9,889 European ancestry class II obese individuals, 2,896 European ancestry class III obese individuals, up to 65,840 European ancestry controls
Replication sample65,332 European ancestry overweight individuals, 22,373 European ancestry class I obese individuals, 5,476 European ancestry class II obese individuals, 1,162 European ancestry class III obese individuals, up to 39,294 European ancestry controls
Region6p12.3
Chromosome idchr6
Chromosome position50830813
Reported geneTFAP2B
Mapped geneTFAP2B
Upstream gene id
Downstream gene id
SNP gene ids7021
Upstream gene distance
Downstream gene distance
SNP risk allelers2206277-T
SNPsrs2206277
Merged0
SNP id current2206277
Contextintron_variant
Intergenic0
Allele frequency0.18
P value5E-22
Pvalue mlog21.3010299956639
P value text(Obesity class I)
Or beta1.12
%95 Ci[NR]
PlatformAffymetrix, Illumina [~ 2800000] (imputed)
CNVN
Mapped traitobesity
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001073
Study accessionGCST001953