Human SNP ID | rs2107595 |
---|---|
Human chromosome | chr7 |
Human SNP position | 19009765 |
Pig chromosome | chr9 |
Pig SNP position | 97240327 |
PubMed ID | 23041239 |
---|---|
Journal | Lancet Neurol |
Link | www.ncbi.nlm.nih.gov/pubmed/23041239 |
Study | Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. |
Disease/Trait | Stroke (ischemic) |
Initial sample | 12,389 European ancestry cases, 62,004 European ancestry controls |
Replication sample | 1,322 Pakistani ancestry cases, 1,143 Pakistani ancestry controls, 12,025 European ancestry cases, 27,940 European ancestry controls |
Region | 7p21.1 |
Chromosome id | chr7 |
Chromosome position | 19009765 |
Reported gene | HDAC9 |
Mapped gene | LOC105375175 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 105375175 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs2107595-A |
SNPs | rs2107595 |
Merged | 0 |
SNP id current | 2107595 |
Context | regulatory_region_variant |
Intergenic | 0 |
Allele frequency | 0.16 |
P value | 0.000004 |
Pvalue mlog | 5.39794000867203 |
P value text | (IS) |
Or beta | 1.12 |
%95 Ci | [1.07-1.17] |
Platform | Affymetrix, Illumina [NR] (imputed) |
CNV | N |
Mapped trait | stroke |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000712 |
Study accession | GCST001706 |
PubMed ID | 23041239 |
Journal | Lancet Neurol |
Link | www.ncbi.nlm.nih.gov/pubmed/23041239 |
Study | Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. |
Disease/Trait | Stroke (ischemic) |
Initial sample | 12,389 European ancestry cases, 62,004 European ancestry controls |
Replication sample | 1,322 Pakistani ancestry cases, 1,143 Pakistani ancestry controls, 12,025 European ancestry cases, 27,940 European ancestry controls |
Region | 7p21.1 |
Chromosome id | chr7 |
Chromosome position | 19009765 |
Reported gene | HDAC9 |
Mapped gene | LOC105375175 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 105375175 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs2107595-A |
SNPs | rs2107595 |
Merged | 0 |
SNP id current | 2107595 |
Context | regulatory_region_variant |
Intergenic | 0 |
Allele frequency | 0.16 |
P value | 0.0000000000000002 |
Pvalue mlog | 15.698970004336 |
P value text | (LVD) |
Or beta | 1.39 |
%95 Ci | [1.27-1.53] |
Platform | Affymetrix, Illumina [NR] (imputed) |
CNV | N |
Mapped trait | stroke |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000712 |
Study accession | GCST001706 |
PubMed ID | 24262325 |
Journal | Stroke |
Link | www.ncbi.nlm.nih.gov/pubmed/24262325 |
Study | Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. |
Disease/Trait | Coronary artery disease or large artery stroke |
Initial sample | 2,167 Large artery stroke cases, 22,233 Coronary artery disease cases, ~ 75,921 controls |
Replication sample | NA |
Region | 7p21.1 |
Chromosome id | chr7 |
Chromosome position | 19009765 |
Reported gene | HDAC9 |
Mapped gene | LOC105375175 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 105375175 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs2107595-? |
SNPs | rs2107595 |
Merged | 0 |
SNP id current | 2107595 |
Context | regulatory_region_variant |
Intergenic | 0 |
Allele frequency | |
P value | 0.000000000003 |
Pvalue mlog | 11.5228787452803 |
P value text | |
Or beta | |
%95 Ci | |
Platform | Affymetrix, Illumina [up to 2500000] (imputed) |
CNV | N |
Mapped trait | large artery stroke, coronary heart disease |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005524, http://www.ebi.ac.uk/efo/EFO_0001645 |
Study accession | GCST002290 |
PubMed ID | 24262325 |
Journal | Stroke |
Link | www.ncbi.nlm.nih.gov/pubmed/24262325 |
Study | Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. |
Disease/Trait | Large artery stroke |
Initial sample | 2,167 cases, 49,159 controls |
Replication sample | NA |
Region | 7p21.1 |
Chromosome id | chr7 |
Chromosome position | 19009765 |
Reported gene | HDAC9 |
Mapped gene | LOC105375175 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 105375175 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs2107595-A |
SNPs | rs2107595 |
Merged | 0 |
SNP id current | 2107595 |
Context | regulatory_region_variant |
Intergenic | 0 |
Allele frequency | |
P value | 0.000000000003 |
Pvalue mlog | 11.5228787452803 |
P value text | |
Or beta | 1.39 |
%95 Ci | [1.27-1.52] |
Platform | Affymetrix, Illumina [~ 2400000] (imputed) |
CNV | N |
Mapped trait | large artery stroke |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005524 |
Study accession | GCST002288 |
PubMed ID | 26343387 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26343387 |
Study | A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. |
Disease/Trait | Coronary artery disease |
Initial sample | 42,096 European ancestry cases, 361 African American cases, 758 Hispanic American cases, 12,658 South Asian ancestry cases, 1,802 Lebanese ancestry cases, 3,614 East Asian ancestry cases, 99,121 European ancestry controls, 2,778 African American controls, |
Replication sample | NA |
Region | 7p21.1 |
Chromosome id | chr7 |
Chromosome position | 19009765 |
Reported gene | HDAC9 |
Mapped gene | LOC105375175 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 105375175 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs2107595-A |
SNPs | rs2107595 |
Merged | 0 |
SNP id current | 2107595 |
Context | regulatory_region_variant |
Intergenic | 0 |
Allele frequency | 0.20047 |
P value | 0.00000000008 |
Pvalue mlog | 10.096910013008 |
P value text | |
Or beta | 1.08 |
%95 Ci | [1.05- 1.10] |
Platform | Affymetrix, Illumina [8600000] (imputed) |
CNV | N |
Mapped trait | coronary artery disease |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000378 |
Study accession | GCST003116 |
PubMed ID | 26390057 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26390057 |
Study | Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. |
Disease/Trait | Pulse pressure |
Initial sample | 31,516 East Asian ancestry individuals, 35,352 European ancestry individuals, 33,126 South Asian ancestry individuals |
Replication sample | 87,205 individuals, 48,268 East Asian ancestry individuals, 68,456 European ancestry individuals and 16,328 South Asian ancestry individuals |
Region | 7p21.1 |
Chromosome id | chr7 |
Chromosome position | 19009765 |
Reported gene | HDAC9 |
Mapped gene | LOC105375175 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 105375175 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs2107595-A |
SNPs | rs2107595 |
Merged | 0 |
SNP id current | 2107595 |
Context | regulatory_region_variant |
Intergenic | 0 |
Allele frequency | 0.230914811571251 |
P value | 0.00000000004 |
Pvalue mlog | 10.397940008672 |
P value text | |
Or beta | 0.30704787 |
%95 Ci | [0.22-0.4] mmHg increase |
Platform | Affymetrix, Illumina, Perlegen [~ 2100000] (imputed) |
CNV | N |
Mapped trait | pulse pressure measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005763 |
Study accession | GCST003274 |
PubMed ID | 26708676 |
Journal | Lancet Neurol |
Link | www.ncbi.nlm.nih.gov/pubmed/26708676 |
Study | Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study. |
Disease/Trait | Ischemic stroke |
Initial sample | 14,300 European ancestry cases, 1,609 African ancestry cases, 942 Hispanic cases, 26,690 European ancestry controls, 3,354 African ancestry controls, 2,429 Hispanic controls |
Replication sample | 996 African ancestry cases, 219 East Asian ancestry cases, 17,334 European ancestry cases, 548 Hispanic cases, 2,385 South Asian ancestry cases, 5,811 African ancestry controls, 329 East Asian ancestry controls, 350,928 European ancestry controls, 686 His |
Region | 7p21.1 |
Chromosome id | chr7 |
Chromosome position | 19009765 |
Reported gene | HDAC9 |
Mapped gene | LOC105375175 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 105375175 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs2107595-A |
SNPs | rs2107595 |
Merged | 0 |
SNP id current | 2107595 |
Context | regulatory_region_variant |
Intergenic | 0 |
Allele frequency | 0.157 |
P value | 0.0000000009 |
Pvalue mlog | 9.04575749056067 |
P value text | |
Or beta | 1.09 |
%95 Ci | [1.06-1.12] |
Platform | Illumina [up to 15400000] (imputed) |
CNV | N |
Mapped trait | Ischemic stroke |
Mapped trait URI | http://purl.obolibrary.org/obo/HP_0002140 |
Study accession | GCST003258 |