SNP Detail For rs2072209
1.Mapping Information
Human SNP ID rs2072209
Human chromosome chr7
Human SNP position 107951753
Pig chromosome chr9
Pig SNP position 118466583
2.Annotation Information
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region7q31.1
Chromosome idchr7
Chromosome position107951753
Reported geneLAMB1
Mapped geneLAMB1
Upstream gene id
Downstream gene id
SNP gene ids3912
Upstream gene distance
Downstream gene distance
SNP risk allelers2072209-G
SNPsrs2072209
Merged0
SNP id current2072209
Contextintron_variant
Intergenic0
Allele frequency0.0582759206419973
P value0.00000001
Pvalue mlog8
P value text(IGP69)
Or beta0.3742
%95 Ci[0.25-0.5] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region7q31.1
Chromosome idchr7
Chromosome position107951753
Reported geneLAMB1
Mapped geneLAMB1
Upstream gene id
Downstream gene id
SNP gene ids3912
Upstream gene distance
Downstream gene distance
SNP risk allelers2072209-G
SNPsrs2072209
Merged0
SNP id current2072209
Contextintron_variant
Intergenic0
Allele frequency0.0584063163538874
P value0.000002
Pvalue mlog5.69897000433601
P value text(IGP74)
Or beta0.3125
%95 Ci[0.18-0.44] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region7q31.1
Chromosome idchr7
Chromosome position107951753
Reported geneLAMB1
Mapped geneLAMB1
Upstream gene id
Downstream gene id
SNP gene ids3912
Upstream gene distance
Downstream gene distance
SNP risk allelers2072209-G
SNPsrs2072209
Merged0
SNP id current2072209
Contextintron_variant
Intergenic0
Allele frequency0.0582759937583593
P value0.0000002
Pvalue mlog6.69897000433601
P value text(IGP75)
Or beta0.3382
%95 Ci[0.21-0.47] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region7q31.1
Chromosome idchr7
Chromosome position107951753
Reported geneLAMB1
Mapped geneLAMB1
Upstream gene id
Downstream gene id
SNP gene ids3912
Upstream gene distance
Downstream gene distance
SNP risk allelers2072209-G
SNPsrs2072209
Merged0
SNP id current2072209
Contextintron_variant
Intergenic0
Allele frequency0.0581724966622163
P value0.000008
Pvalue mlog5.09691001300805
P value text(IGP76)
Or beta0.2906
%95 Ci[0.16-0.42] unit increase
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848