SNP Detail For rs2071449
1.Mapping Information
Human SNP ID rs2071449
Human chromosome chr12
Human SNP position 54034227
Pig chromosome chr5
Pig SNP position 20148196
2.Annotation Information
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region12q13.13
Chromosome idchr12
Chromosome position54034227
Reported geneHOXC4, HOXC6
Mapped geneHOXC4, HOXC5
Upstream gene id
Downstream gene id
SNP gene ids3221, 3222
Upstream gene distance
Downstream gene distance
SNP risk allelers2071449-A
SNPsrs2071449
Merged0
SNP id current2071449
Contextintron_variant
Intergenic0
Allele frequency0.3669
P value0.00000004
Pvalue mlog7.39794000867203
P value text(EA, women)
Or beta0.0265
%95 Ci[0.017-0.036] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region12q13.13
Chromosome idchr12
Chromosome position54034227
Reported geneHOXC4, HOXC6
Mapped geneHOXC4, HOXC5
Upstream gene id
Downstream gene id
SNP gene ids3221, 3222
Upstream gene distance
Downstream gene distance
SNP risk allelers2071449-A
SNPsrs2071449
Merged0
SNP id current2071449
Contextintron_variant
Intergenic0
Allele frequency0.3715
P value0.00000003
Pvalue mlog7.52287874528033
P value text(EA, men)
Or beta0.0287
%95 Ci[0.019-0.039] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region12q13.13
Chromosome idchr12
Chromosome position54034227
Reported geneHOXC4, HOXC6
Mapped geneHOXC4, HOXC5
Upstream gene id
Downstream gene id
SNP gene ids3221, 3222
Upstream gene distance
Downstream gene distance
SNP risk allelers2071449-A
SNPsrs2071449
Merged0
SNP id current2071449
Contextintron_variant
Intergenic0
Allele frequency0.3692
P value0.00000000000003
Pvalue mlog13.5228787452803
P value text(EA)
Or beta0.0276
%95 Ci[0.021-0.035] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region12q13.13
Chromosome idchr12
Chromosome position54034227
Reported geneHOXC4, HOXC6
Mapped geneHOXC4, HOXC5
Upstream gene id
Downstream gene id
SNP gene ids3221, 3222
Upstream gene distance
Downstream gene distance
SNP risk allelers2071449-A
SNPsrs2071449
Merged0
SNP id current2071449
Contextintron_variant
Intergenic0
Allele frequency0.368
P value0.0000002
Pvalue mlog6.69897000433601
P value text(men)
Or beta0.0265
%95 Ci[0.017-0.036] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region12q13.13
Chromosome idchr12
Chromosome position54034227
Reported geneHOXC4, HOXC6
Mapped geneHOXC4, HOXC5
Upstream gene id
Downstream gene id
SNP gene ids3221, 3222
Upstream gene distance
Downstream gene distance
SNP risk allelers2071449-A
SNPsrs2071449
Merged0
SNP id current2071449
Contextintron_variant
Intergenic0
Allele frequency0.3623
P value0.00000005
Pvalue mlog7.30102999566398
P value text(women)
Or beta0.0261
%95 Ci[0.017-0.036] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region12q13.13
Chromosome idchr12
Chromosome position54034227
Reported geneHOXC4, HOXC6
Mapped geneHOXC4, HOXC5
Upstream gene id
Downstream gene id
SNP gene ids3221, 3222
Upstream gene distance
Downstream gene distance
SNP risk allelers2071449-A
SNPsrs2071449
Merged0
SNP id current2071449
Contextintron_variant
Intergenic0
Allele frequency0.3637
P value0.0000000000003
Pvalue mlog12.5228787452803
P value text
Or beta0.0261
%95 Ci[0.019-0.033] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782