Human SNP ID | rs20541 |
---|---|
Human chromosome | chr5 |
Human SNP position | 132660272 |
Pig chromosome | chr2 |
Pig SNP position | 140443258 |
PubMed ID | 22075330 |
---|---|
Journal | J Allergy Clin Immunol |
Link | www.ncbi.nlm.nih.gov/pubmed/22075330 |
Study | A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. |
Disease/Trait | IgE levels |
Initial sample | 6,819 European ancestry individuals |
Replication sample | 7,809 European ancestry indivduals |
Region | 5q31.1 |
Chromosome id | chr5 |
Chromosome position | 132660272 |
Reported gene | IL13 |
Mapped gene | IL13 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 3596 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs20541-A |
SNPs | rs20541 |
Merged | 0 |
SNP id current | 20541 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.000000000000000003 |
Pvalue mlog | 17.5228787452803 |
P value text | |
Or beta | 0.08 |
%95 Ci | [NR] unit increase |
Platform | Affymetrix [2540223] (imputed) |
CNV | N |
Mapped trait | serum IgE measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004579 |
Study accession | GCST001316 |
PubMed ID | 19169254 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/19169254 |
Study | Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. |
Disease/Trait | Psoriasis |
Initial sample | 1,359 European ancestry cases, 1,400 European ancestry controls |
Replication sample | 5,048 European ancestry cases, 5,041 European ancestry controls |
Region | 5q31.1 |
Chromosome id | chr5 |
Chromosome position | 132660272 |
Reported gene | IL13 |
Mapped gene | IL13 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 3596 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs20541-G |
SNPs | rs20541 |
Merged | 0 |
SNP id current | 20541 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | 0.79 |
P value | 0.000000000000005 |
Pvalue mlog | 14.3010299956639 |
P value text | |
Or beta | 1.27 |
%95 Ci | [NR] |
Platform | Perlegen [~ 2500000] (imputed) |
CNV | N |
Mapped trait | psoriasis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000676 |
Study accession | GCST000322 |
PubMed ID | 22286212 |
Journal | J Natl Cancer Inst |
Link | www.ncbi.nlm.nih.gov/pubmed/22286212 |
Study | Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. |
Disease/Trait | Hodgkin__s lymphoma |
Initial sample | 1,200 European ancestry cases, 6,417 European ancestry controls |
Replication sample | 563 European ancestry cases, 613 European ancestry controls |
Region | 5q31.1 |
Chromosome id | chr5 |
Chromosome position | 132660272 |
Reported gene | IL13 |
Mapped gene | IL13 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 3596 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs20541-? |
SNPs | rs20541 |
Merged | 0 |
SNP id current | 20541 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.00000001 |
Pvalue mlog | 8 |
P value text | (EBV-negative cHL) |
Or beta | 1.47 |
%95 Ci | [1.29-1.68] |
Platform | Illumina [502514] |
CNV | N |
Mapped trait | Hodgkins lymphoma |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000183 |
Study accession | GCST001387 |
PubMed ID | 23817569 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23817569 |
Study | A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. |
Disease/Trait | Self-reported allergy |
Initial sample | 53,862 European ancestry individuals |
Replication sample | NA |
Region | 5q31.1 |
Chromosome id | chr5 |
Chromosome position | 132660272 |
Reported gene | intergenic |
Mapped gene | IL13 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 3596 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs20541-A |
SNPs | rs20541 |
Merged | 0 |
SNP id current | 20541 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | 0.2019 |
P value | 0.000001 |
Pvalue mlog | 6 |
P value text | |
Or beta | 0.0724 |
%95 Ci | [0.043-0.101] unit increase |
Platform | Illumina [2400000] (imputed) |
CNV | N |
Mapped trait | allergy |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0003785 |
Study accession | GCST002083 |
PubMed ID | 25574825 |
Journal | Am J Hum Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/25574825 |
Study | Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms. |
Disease/Trait | Psoriasis |
Initial sample | 4,212 European ancestry cases, 8,032 European ancestry controls |
Replication sample | NA |
Region | 5q31.1 |
Chromosome id | chr5 |
Chromosome position | 132660272 |
Reported gene | IL13, IL4 |
Mapped gene | IL13 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 3596 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs20541-A |
SNPs | rs20541 |
Merged | 0 |
SNP id current | 20541 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.000005 |
Pvalue mlog | 5.30102999566398 |
P value text | |
Or beta | 1.1890606 |
%95 Ci | [1.14-1.23] |
Platform | Affymetrix, Illumina, Perlegen [up to 5493100] (imputed) |
CNV | N |
Mapped trait | psoriasis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000676 |
Study accession | GCST002738 |
PubMed ID | 25903422 |
Journal | Nat Commun |
Link | www.ncbi.nlm.nih.gov/pubmed/25903422 |
Study | Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. |
Disease/Trait | Psoriasis |
Initial sample | 3,496 European ancestry cases, 5,186 European ancestry controls, 1,588 Chinese ancestry cases, 3,546 Chinese ancestry controls |
Replication sample | 5,134 European ancestry cases, 5,633 European ancestry controls, 5,151 Chinese ancestry cases, 5,152 Chinese ancestry controls |
Region | 5q31.1 |
Chromosome id | chr5 |
Chromosome position | 132660272 |
Reported gene | IL13 |
Mapped gene | IL13 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 3596 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs20541-G |
SNPs | rs20541 |
Merged | 0 |
SNP id current | 20541 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | 0.79 |
P value | 0.000000005 |
Pvalue mlog | 8.30102999566398 |
P value text | |
Or beta | 1.14 |
%95 Ci | [1.09-1.19] |
Platform | Illumina [up to 4778154] (imputed) |
CNV | N |
Mapped trait | psoriasis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000676 |
Study accession | GCST002874 |
PubMed ID | 26626624 |
Journal | Am J Hum Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26626624 |
Study | Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture. |
Disease/Trait | Cutaneous psoriasis |
Initial sample | 1,363 European ancestry cases, 4,934 European ancestry controls |
Replication sample | up to 2,969 European ancestry cases, up to European ancestry 14,384 controls |
Region | 5q31.1 |
Chromosome id | chr5 |
Chromosome position | 132660272 |
Reported gene | IL13 |
Mapped gene | IL13 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 3596 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs20541-G |
SNPs | rs20541 |
Merged | 0 |
SNP id current | 20541 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.00000003 |
Pvalue mlog | 7.52287874528033 |
P value text | |
Or beta | 1.237 |
%95 Ci | NR |
Platform | Illumina [11532644] (imputed) |
CNV | N |
Mapped trait | psoriasis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000676 |
Study accession | GCST003269 |