Human SNP ID | rs2036527 |
---|---|
Human chromosome | chr15 |
Human SNP position | 78559273 |
Pig chromosome | chr7 |
Pig SNP position | 52922448 |
PubMed ID | 21946350 |
---|---|
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/21946350 |
Study | Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. |
Disease/Trait | Pulmonary function |
Initial sample | 48,201 European ancestry individuals |
Replication sample | 46,411 European ancestry individuals |
Region | 15q25.1 |
Chromosome id | chr15 |
Chromosome position | 78559273 |
Reported gene | CHRNA5 |
Mapped gene | PSMA4 - CHRNA5 |
Upstream gene id | 5685 |
Downstream gene id | 1138 |
SNP gene ids | |
Upstream gene distance | 10053 |
Downstream gene distance | 6247 |
SNP risk allele | rs2036527-G |
SNPs | rs2036527 |
Merged | 0 |
SNP id current | 2036527 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | NR |
P value | 0.0000007 |
Pvalue mlog | 6.15490195998574 |
P value text | (FEV1) |
Or beta | 0.026 |
%95 Ci | [0.016-0.036] unit increase |
Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | pulmonary function measurement, forced expiratory volume |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0003892, http://www.ebi.ac.uk/efo/EFO_0004314 |
Study accession | GCST001251 |
PubMed ID | 22832964 |
Journal | Transl Psychiatry |
Link | www.ncbi.nlm.nih.gov/pubmed/22832964 |
Study | Genome-wide meta-analyses of smoking behaviors in African Americans. |
Disease/Trait | Smoking behavior |
Initial sample | Up to 32,389 African American individuals |
Replication sample | NA |
Region | 15q25.1 |
Chromosome id | chr15 |
Chromosome position | 78559273 |
Reported gene | CHRNA5 |
Mapped gene | PSMA4 - CHRNA5 |
Upstream gene id | 5685 |
Downstream gene id | 1138 |
SNP gene ids | |
Upstream gene distance | 10053 |
Downstream gene distance | 6247 |
SNP risk allele | rs2036527-A |
SNPs | rs2036527 |
Merged | 0 |
SNP id current | 2036527 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | 0.22 |
P value | 0.00000002 |
Pvalue mlog | 7.69897000433601 |
P value text | (CPD) |
Or beta | 0.04 |
%95 Ci | [0.026-0.054] unit increase |
Platform | Affymetrix, Illumina [~ 2900000] (imputed) |
CNV | N |
Mapped trait | smoking behavior |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004318 |
Study accession | GCST001539 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Post bronchodilator FEV1 |
Initial sample | 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals |
Replication sample | NA |
Region | 15q25.1 |
Chromosome id | chr15 |
Chromosome position | 78559273 |
Reported gene | Intergenic |
Mapped gene | PSMA4 - CHRNA5 |
Upstream gene id | 5685 |
Downstream gene id | 1138 |
SNP gene ids | |
Upstream gene distance | 10053 |
Downstream gene distance | 6247 |
SNP risk allele | rs2036527-A |
SNPs | rs2036527 |
Merged | 0 |
SNP id current | 2036527 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | 0.6 |
P value | 0.000000000000009 |
Pvalue mlog | 14.0457574905606 |
P value text | |
Or beta | 0.071 |
%95 Ci | NR unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | forced expiratory volume, response to bronchodilator |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004314, http://purl.obolibrary.org/obo/GO_0097366 |
Study accession | GCST003262 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Post bronchodilator FEV1/FVC ratio in COPD |
Initial sample | 5,439 European ancestry current and former smoker cases, 821 African American current and former smoker cases |
Replication sample | NA |
Region | 15q25.1 |
Chromosome id | chr15 |
Chromosome position | 78559273 |
Reported gene | Intergenic |
Mapped gene | PSMA4 - CHRNA5 |
Upstream gene id | 5685 |
Downstream gene id | 1138 |
SNP gene ids | |
Upstream gene distance | 10053 |
Downstream gene distance | 6247 |
SNP risk allele | rs2036527-A |
SNPs | rs2036527 |
Merged | 0 |
SNP id current | 2036527 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | 0.504 |
P value | 0.0000007 |
Pvalue mlog | 6.15490195998574 |
P value text | |
Or beta | 0.012 |
%95 Ci | NR unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | response to bronchodilator, chronic obstructive pulmonary disease, FEV/FEC ratio |
Mapped trait URI | http://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0000341, http://www.ebi.ac.uk/efo/EFO_0004713 |
Study accession | GCST003265 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Pre bronchodilator FEV1 |
Initial sample | 6,659 European ancestry current and former smoker individuals |
Replication sample | NA |
Region | 15q25.1 |
Chromosome id | chr15 |
Chromosome position | 78559273 |
Reported gene | CHRNA5 |
Mapped gene | PSMA4 - CHRNA5 |
Upstream gene id | 5685 |
Downstream gene id | 1138 |
SNP gene ids | |
Upstream gene distance | 10053 |
Downstream gene distance | 6247 |
SNP risk allele | rs2036527NR |
SNPs | rs2036527 |
Merged | 0 |
SNP id current | 2036527 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | NR |
P value | 0.000000002 |
Pvalue mlog | 8.69897000433601 |
P value text | |
Or beta | 0.08021 |
%95 Ci | unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | forced expiratory volume |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004314 |
Study accession | GCST003266 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Pre bronchodilator FEV1/FVC ratio |
Initial sample | 6,659 European ancestry current and former smoker individuals |
Replication sample | NA |
Region | 15q25.1 |
Chromosome id | chr15 |
Chromosome position | 78559273 |
Reported gene | CHRNA5 |
Mapped gene | PSMA4 - CHRNA5 |
Upstream gene id | 5685 |
Downstream gene id | 1138 |
SNP gene ids | |
Upstream gene distance | 10053 |
Downstream gene distance | 6247 |
SNP risk allele | rs2036527-? |
SNPs | rs2036527 |
Merged | 0 |
SNP id current | 2036527 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | NR |
P value | 0.0000000004 |
Pvalue mlog | 9.39794000867203 |
P value text | |
Or beta | 0.01665 |
%95 Ci | unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | FEV/FEC ratio |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004713 |
Study accession | GCST003267 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Post bronchodilator FEV1/FVC ratio |
Initial sample | 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals |
Replication sample | NA |
Region | 15q25.1 |
Chromosome id | chr15 |
Chromosome position | 78559273 |
Reported gene | Intergenic |
Mapped gene | PSMA4 - CHRNA5 |
Upstream gene id | 5685 |
Downstream gene id | 1138 |
SNP gene ids | |
Upstream gene distance | 10053 |
Downstream gene distance | 6247 |
SNP risk allele | rs2036527-A |
SNPs | rs2036527 |
Merged | 0 |
SNP id current | 2036527 |
Context | intergenic_variant |
Intergenic | 1 |
Allele frequency | 0.601 |
P value | 0.0000000000000007 |
Pvalue mlog | 15.1549019599857 |
P value text | |
Or beta | 0.015 |
%95 Ci | unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | response to bronchodilator, FEV/FEC ratio |
Mapped trait URI | http://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0004713 |
Study accession | GCST003264 |