SNP Detail For rs1858037
1.Mapping Information
Human SNP ID rs1858037
Human chromosome chr2
Human SNP position 65371166
Pig chromosome chr3
Pig SNP position 80384493
2.Annotation Information
PubMed ID24390342
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/24390342
StudyGenetics of rheumatoid arthritis contributes to biology and drug discovery.
Disease/TraitRheumatoid arthritis
Initial sampleup to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls
Replication sampleup to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls
Region2p14
Chromosome idchr2
Chromosome position65371166
Reported geneSPRED2
Mapped geneSPRED2
Upstream gene id
Downstream gene id
SNP gene ids200734
Upstream gene distance
Downstream gene distance
SNP risk allelers1858037-T
SNPsrs1858037
Merged0
SNP id current1858037
Contextintron_variant
Intergenic0
Allele frequency0.52
P value0.000000000000003
Pvalue mlog14.5228787452803
P value text
Or beta1.11
%95 Ci[1.08-1.14]
PlatformAffymetrix, Illumina [up to 9739303] (imputed)
CNVN
Mapped traitrheumatoid arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685
Study accessionGCST002318
PubMed ID24390342
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/24390342
StudyGenetics of rheumatoid arthritis contributes to biology and drug discovery.
Disease/TraitRheumatoid arthritis
Initial sampleup to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls
Replication sampleup to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls
Region2p14
Chromosome idchr2
Chromosome position65371166
Reported geneSPRED2
Mapped geneSPRED2
Upstream gene id
Downstream gene id
SNP gene ids200734
Upstream gene distance
Downstream gene distance
SNP risk allelers1858037-T
SNPsrs1858037
Merged0
SNP id current1858037
Contextintron_variant
Intergenic0
Allele frequency0.65
P value0.000000002
Pvalue mlog8.69897000433601
P value text(EA)
Or beta1.09
%95 Ci[1.06-1.13]
PlatformAffymetrix, Illumina [up to 9739303] (imputed)
CNVN
Mapped traitrheumatoid arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685
Study accessionGCST002318
PubMed ID24390342
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/24390342
StudyGenetics of rheumatoid arthritis contributes to biology and drug discovery.
Disease/TraitRheumatoid arthritis
Initial sampleup to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls
Replication sampleup to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls
Region2p14
Chromosome idchr2
Chromosome position65371166
Reported geneSPRED2
Mapped geneSPRED2
Upstream gene id
Downstream gene id
SNP gene ids200734
Upstream gene distance
Downstream gene distance
SNP risk allelers1858037-T
SNPsrs1858037
Merged0
SNP id current1858037
Contextintron_variant
Intergenic0
Allele frequency0.16
P value0.00000001
Pvalue mlog8
P value text(East Asian)
Or beta1.19
%95 Ci[1.12-1.26]
PlatformAffymetrix, Illumina [up to 9739303] (imputed)
CNVN
Mapped traitrheumatoid arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685
Study accessionGCST002318