SNP Detail For rs1837253
1.Mapping Information
Human SNP ID rs1837253
Human chromosome chr5
Human SNP position 111066174
Pig chromosome chr2
Pig SNP position 120313819
2.Annotation Information
PubMed ID21804549
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21804549
StudyMeta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Disease/TraitAsthma
Initial sample2,088 European ancestry cases, 1,612 African American and African Caribbean cases, 1,688 Hispanic cases
Replication sample2,727 European ancestry cases, 2,147 African American and African Caribbean cases, 2,299 Hispanic cases
Region5q22.1
Chromosome idchr5
Chromosome position111066174
Reported geneTSLP
Mapped geneLOC105379121 - TSLP
Upstream gene id105379121
Downstream gene id85480
SNP gene ids
Upstream gene distance51554
Downstream gene distance3906
SNP risk allelers1837253-?
SNPsrs1837253
Merged0
SNP id current1837253
Contextupstream_gene_variant
Intergenic1
Allele frequencyNR
P value0.00000000000001
Pvalue mlog14
P value text
Or beta
%95 Ci
PlatformAffymetrix, Illumina [> 2000000] (imputed)
CNVN
Mapped traitasthma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000270
Study accessionGCST001182
PubMed ID21804548
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21804548
StudyGenome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
Disease/TraitAsthma
Initial sample1,532 Japanese ancestry cases, 3,304 Japanese ancestry controls
Replication sample5,639 Japanese ancestry cases, 24,608 Japanese ancestry controls
Region5q22.1
Chromosome idchr5
Chromosome position111066174
Reported geneTSLP
Mapped geneLOC105379121 - TSLP
Upstream gene id105379121
Downstream gene id85480
SNP gene ids
Upstream gene distance51554
Downstream gene distance3906
SNP risk allelers1837253-C
SNPsrs1837253
Merged0
SNP id current1837253
Contextupstream_gene_variant
Intergenic1
Allele frequency0.35
P value0.0000000000000001
Pvalue mlog16
P value text
Or beta1.17
%95 Ci[1.13-1.22]
PlatformIllumina [458847]
CNVN
Mapped traitasthma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000270
Study accessionGCST001183
PubMed ID24388013
JournalJ Allergy Clin Immunol
Linkwww.ncbi.nlm.nih.gov/pubmed/24388013
StudyGenome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
Disease/TraitAsthma and hay fever
Initial sample6,685 European ancestry cases, 14,091 European ancestry controls
Replication sample878 European ancestry cases, 2,455 European ancestry controls
Region5q22.1
Chromosome idchr5
Chromosome position111066174
Reported geneTSLP
Mapped geneLOC105379121 - TSLP
Upstream gene id105379121
Downstream gene id85480
SNP gene ids
Upstream gene distance51554
Downstream gene distance3906
SNP risk allelers1837253-C
SNPsrs1837253
Merged0
SNP id current1837253
Contextupstream_gene_variant
Intergenic1
Allele frequency0.71
P value0.000000001
Pvalue mlog9
P value text
Or beta1.17
%95 Ci[1.12-1.24]
PlatformIllumina [up to 4972397] (imputed)
CNVN
Mapped traitseasonal allergic rhinitis, asthma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003956, http://www.ebi.ac.uk/efo/EFO_0000270
Study accessionGCST002322