SNP Detail For rs1805081
1.Mapping Information
Human SNP ID rs1805081
Human chromosome chr18
Human SNP position 23560468
Pig chromosome chr6
Pig SNP position 101028838
2.Annotation Information
PubMed ID19151714
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/19151714
StudyGenome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
Disease/TraitObesity
Initial sample695 European ancestry adult cases, 731 European ancestry adult controls, 685 European ancestry child cases, 685 European ancestry child controls
Replication sample1,171 European ancestry adult cases, 1,114 European ancestry adult controls, 4,417 European ancestry adults, 896 European ancestry child cases, 1,297 European ancestry child and young adult controls, 5,291 European ancestry children
Region18q11.2
Chromosome idchr18
Chromosome position23560468
Reported geneNPC1
Mapped geneNPC1
Upstream gene id
Downstream gene id
SNP gene ids4864
Upstream gene distance
Downstream gene distance
SNP risk allelers1805081-A
SNPsrs1805081
Merged0
SNP id current1805081
Contextmissense_variant
Intergenic0
Allele frequency0.56
P value0.0000003
Pvalue mlog6.52287874528033
P value text
Or beta
%95 Ci
PlatformIllumina [308846]
CNVN
Mapped traitobesity
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001073
Study accessionGCST000317
PubMed ID19151714
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/19151714
StudyGenome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
Disease/TraitObesity
Initial sample695 European ancestry adult cases, 731 European ancestry adult controls, 685 European ancestry child cases, 685 European ancestry child controls
Replication sample1,171 European ancestry adult cases, 1,114 European ancestry adult controls, 4,417 European ancestry adults, 896 European ancestry child cases, 1,297 European ancestry child and young adult controls, 5,291 European ancestry children
Region18q11.2
Chromosome idchr18
Chromosome position23560468
Reported geneNPC1
Mapped geneNPC1
Upstream gene id
Downstream gene id
SNP gene ids4864
Upstream gene distance
Downstream gene distance
SNP risk allelers1805081-A
SNPsrs1805081
Merged0
SNP id current1805081
Contextmissense_variant
Intergenic0
Allele frequency0.6
P value0.00000008
Pvalue mlog7.09691001300805
P value text(adults)
Or beta1.41
%95 Ci[1.19-1.61]
PlatformIllumina [308846]
CNVN
Mapped traitobesity
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001073
Study accessionGCST000317