SNP Detail For rs1801282
1.Mapping Information
Human SNP ID rs1801282
Human chromosome chr3
Human SNP position 12351626
Pig chromosome chr13
Pig SNP position 75578209
2.Annotation Information
PubMed ID17463246
JournalScience
Linkwww.ncbi.nlm.nih.gov/pubmed/17463246
StudyGenome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
Disease/TraitType 2 diabetes
Initial sample1,464 European ancestry cases, 1,467 European ancestry controls
Replication sample5,065 European ancestry cases, 5,785 European ancestry controls
Region3p25.2
Chromosome idchr3
Chromosome position12351626
Reported genePPARG
Mapped genePPARG
Upstream gene id
Downstream gene id
SNP gene ids5468
Upstream gene distance
Downstream gene distance
SNP risk allelers1801282-C
SNPsrs1801282
Merged0
SNP id current1801282
Contextmissense_variant
Intergenic0
Allele frequency0.86
P value0.000002
Pvalue mlog5.69897000433601
P value text(DGI+FUSION+WTCCC)
Or beta1.14
%95 Ci[1.08-1.20]
PlatformAffymetrix [386731]
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST000028
PubMed ID17463249
JournalScience
Linkwww.ncbi.nlm.nih.gov/pubmed/17463249
StudyReplication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
Disease/TraitType 2 diabetes
Initial sample1,924 European ancestry cases, 2,938 European ancestry controls
Replication sample3,757 European ancestry cases, 5,346 European ancestry controls
Region3p25.2
Chromosome idchr3
Chromosome position12351626
Reported genePPARG
Mapped genePPARG
Upstream gene id
Downstream gene id
SNP gene ids5468
Upstream gene distance
Downstream gene distance
SNP risk allelers1801282-C
SNPsrs1801282
Merged0
SNP id current1801282
Contextmissense_variant
Intergenic0
Allele frequencyNR
P value0.000002
Pvalue mlog5.69897000433601
P value text(DGI+FUSION+WTCCC)
Or beta1.14
%95 Ci[1.08-1.20]
PlatformAffymetrix [393453]
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST000025
PubMed ID17463248
JournalScience
Linkwww.ncbi.nlm.nih.gov/pubmed/17463248
StudyA genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
Disease/TraitType 2 diabetes
Initial sample1,161 European ancestry cases, 1,174 European ancestry controls
Replication sample1,215 European ancestry cases, 1,258 European ancestry controls
Region3p25.2
Chromosome idchr3
Chromosome position12351626
Reported genePPARG
Mapped genePPARG
Upstream gene id
Downstream gene id
SNP gene ids5468
Upstream gene distance
Downstream gene distance
SNP risk allelers1801282-C
SNPsrs1801282
Merged0
SNP id current1801282
Contextmissense_variant
Intergenic0
Allele frequency0.82
P value0.000002
Pvalue mlog5.69897000433601
P value text(DGI+FUSION+WTCCC)
Or beta1.14
%95 Ci[1.08-1.20]
PlatformIllumina [315635]
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST000024
PubMed ID22581228
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22581228
StudyA genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Disease/TraitFasting insulin-related traits (interaction with BMI)
Initial sampleUp to 51,750 European ancestry individuals
Replication sampleUp to 33,823 European ancestry individuals
Region3p25.2
Chromosome idchr3
Chromosome position12351626
Reported genePPARG
Mapped genePPARG
Upstream gene id
Downstream gene id
SNP gene ids5468
Upstream gene distance
Downstream gene distance
SNP risk allelers1801282-?
SNPsrs1801282
Merged0
SNP id current1801282
Contextmissense_variant
Intergenic0
Allele frequencyNR
P value0.0000002
Pvalue mlog6.69897000433601
P value text
Or beta
%95 Ci
PlatformAffymetrix, Illumina [~ 2400000] (imputed)
CNVN
Mapped traitbody mass index, fasting blood insulin measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340, http://www.ebi.ac.uk/efo/EFO_0004466
Study accessionGCST001526
PubMed ID24509480
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24509480
StudyGenome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Disease/TraitType 2 diabetes
Initial sample12,171 European ancestry cases, 56,862 European ancestry controls, 6,952 East Asian ancestry cases, 11,865 East Asian ancestry controls, 5,561 South Asian ancestry cases, 14,458 South Asian ancestry controls, 1,804 Mexican ancestry cases, 779 Mexican ance
Replication sample21,491 European ancestry cases, 55,647 European ancestry controls
Region3p25.2
Chromosome idchr3
Chromosome position12351626
Reported genePPARG
Mapped genePPARG
Upstream gene id
Downstream gene id
SNP gene ids5468
Upstream gene distance
Downstream gene distance
SNP risk allelers1801282-C
SNPsrs1801282
Merged0
SNP id current1801282
Contextmissense_variant
Intergenic0
Allele frequency0.88
P value0.0000000006
Pvalue mlog9.22184874961635
P value text
Or beta1.16
%95 Ci[1.10-1.23]
PlatformAffymetrix, Illumina [2500000] (imputed)
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST002352