Human SNP ID | rs1801282 |
---|---|
Human chromosome | chr3 |
Human SNP position | 12351626 |
Pig chromosome | chr13 |
Pig SNP position | 75578209 |
PubMed ID | 17463246 |
---|---|
Journal | Science |
Link | www.ncbi.nlm.nih.gov/pubmed/17463246 |
Study | Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. |
Disease/Trait | Type 2 diabetes |
Initial sample | 1,464 European ancestry cases, 1,467 European ancestry controls |
Replication sample | 5,065 European ancestry cases, 5,785 European ancestry controls |
Region | 3p25.2 |
Chromosome id | chr3 |
Chromosome position | 12351626 |
Reported gene | PPARG |
Mapped gene | PPARG |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 5468 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1801282-C |
SNPs | rs1801282 |
Merged | 0 |
SNP id current | 1801282 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | 0.86 |
P value | 0.000002 |
Pvalue mlog | 5.69897000433601 |
P value text | (DGI+FUSION+WTCCC) |
Or beta | 1.14 |
%95 Ci | [1.08-1.20] |
Platform | Affymetrix [386731] |
CNV | N |
Mapped trait | type II diabetes mellitus |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0001360 |
Study accession | GCST000028 |
PubMed ID | 17463249 |
Journal | Science |
Link | www.ncbi.nlm.nih.gov/pubmed/17463249 |
Study | Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. |
Disease/Trait | Type 2 diabetes |
Initial sample | 1,924 European ancestry cases, 2,938 European ancestry controls |
Replication sample | 3,757 European ancestry cases, 5,346 European ancestry controls |
Region | 3p25.2 |
Chromosome id | chr3 |
Chromosome position | 12351626 |
Reported gene | PPARG |
Mapped gene | PPARG |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 5468 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1801282-C |
SNPs | rs1801282 |
Merged | 0 |
SNP id current | 1801282 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.000002 |
Pvalue mlog | 5.69897000433601 |
P value text | (DGI+FUSION+WTCCC) |
Or beta | 1.14 |
%95 Ci | [1.08-1.20] |
Platform | Affymetrix [393453] |
CNV | N |
Mapped trait | type II diabetes mellitus |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0001360 |
Study accession | GCST000025 |
PubMed ID | 17463248 |
Journal | Science |
Link | www.ncbi.nlm.nih.gov/pubmed/17463248 |
Study | A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. |
Disease/Trait | Type 2 diabetes |
Initial sample | 1,161 European ancestry cases, 1,174 European ancestry controls |
Replication sample | 1,215 European ancestry cases, 1,258 European ancestry controls |
Region | 3p25.2 |
Chromosome id | chr3 |
Chromosome position | 12351626 |
Reported gene | PPARG |
Mapped gene | PPARG |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 5468 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1801282-C |
SNPs | rs1801282 |
Merged | 0 |
SNP id current | 1801282 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | 0.82 |
P value | 0.000002 |
Pvalue mlog | 5.69897000433601 |
P value text | (DGI+FUSION+WTCCC) |
Or beta | 1.14 |
%95 Ci | [1.08-1.20] |
Platform | Illumina [315635] |
CNV | N |
Mapped trait | type II diabetes mellitus |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0001360 |
Study accession | GCST000024 |
PubMed ID | 22581228 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/22581228 |
Study | A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. |
Disease/Trait | Fasting insulin-related traits (interaction with BMI) |
Initial sample | Up to 51,750 European ancestry individuals |
Replication sample | Up to 33,823 European ancestry individuals |
Region | 3p25.2 |
Chromosome id | chr3 |
Chromosome position | 12351626 |
Reported gene | PPARG |
Mapped gene | PPARG |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 5468 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1801282-? |
SNPs | rs1801282 |
Merged | 0 |
SNP id current | 1801282 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.0000002 |
Pvalue mlog | 6.69897000433601 |
P value text | |
Or beta | |
%95 Ci | |
Platform | Affymetrix, Illumina [~ 2400000] (imputed) |
CNV | N |
Mapped trait | body mass index, fasting blood insulin measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004340, http://www.ebi.ac.uk/efo/EFO_0004466 |
Study accession | GCST001526 |
PubMed ID | 24509480 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/24509480 |
Study | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. |
Disease/Trait | Type 2 diabetes |
Initial sample | 12,171 European ancestry cases, 56,862 European ancestry controls, 6,952 East Asian ancestry cases, 11,865 East Asian ancestry controls, 5,561 South Asian ancestry cases, 14,458 South Asian ancestry controls, 1,804 Mexican ancestry cases, 779 Mexican ance |
Replication sample | 21,491 European ancestry cases, 55,647 European ancestry controls |
Region | 3p25.2 |
Chromosome id | chr3 |
Chromosome position | 12351626 |
Reported gene | PPARG |
Mapped gene | PPARG |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 5468 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1801282-C |
SNPs | rs1801282 |
Merged | 0 |
SNP id current | 1801282 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | 0.88 |
P value | 0.0000000006 |
Pvalue mlog | 9.22184874961635 |
P value text | |
Or beta | 1.16 |
%95 Ci | [1.10-1.23] |
Platform | Affymetrix, Illumina [2500000] (imputed) |
CNV | N |
Mapped trait | type II diabetes mellitus |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0001360 |
Study accession | GCST002352 |