SNP Detail For rs1800789
1.Mapping Information
Human SNP ID rs1800789
Human chromosome chr4
Human SNP position 154561591
Pig chromosome chr8
Pig SNP position 78963477
2.Annotation Information
PubMed ID20031576
JournalCirc Cardiovasc Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20031576
StudyAssociation of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.
Disease/TraitFibrinogen
Initial sample22,096 European ancestry individuals
Replication sample17,686 European ancestry female individuals
Region4q31.3
Chromosome idchr4
Chromosome position154561591
Reported geneFGB
Mapped genePLRG1 - FGB
Upstream gene id5356
Downstream gene id2244
SNP gene ids
Upstream gene distance11158
Downstream gene distance1389
SNP risk allelers1800789-A
SNPsrs1800789
Merged0
SNP id current1800789
Contextupstream_gene_variant
Intergenic1
Allele frequency0.22
P value2E-30
Pvalue mlog29.698970004336
P value text
Or beta0.09
%95 Ci[0.07-0.11] g/L increase
PlatformAffymetrix, Illumina [~ 2661766] (imputed)
CNVN
Mapped traitfibrinogen measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004623
Study accessionGCST000366
PubMed ID23969696
JournalCirculation
Linkwww.ncbi.nlm.nih.gov/pubmed/23969696
StudyMultiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
Disease/TraitFibrinogen
Initial sample91,323 European ancestry individuals
Replication sample8,423 African American individuals, 1,447 Hispanic individuals
Region4q31.3
Chromosome idchr4
Chromosome position154561591
Reported geneFGB
Mapped genePLRG1 - FGB
Upstream gene id5356
Downstream gene id2244
SNP gene ids
Upstream gene distance11158
Downstream gene distance1389
SNP risk allelers1800789-A
SNPsrs1800789
Merged0
SNP id current1800789
Contextupstream_gene_variant
Intergenic1
Allele frequency0.21
P value2E-127
Pvalue mlog126.698970004336
P value text
Or beta0.031
%95 Ci[0.029-0.033] unit increase
PlatformAffymetrix, Illumina [2515567] (imputed)
CNVN
Mapped traitfibrinogen measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004623
Study accessionGCST002147