SNP Detail For rs17518584
1.Mapping Information
Human SNP ID rs17518584
Human chromosome chr3
Human SNP position 85555773
Pig chromosome chr13
Pig SNP position 181277774
2.Annotation Information
PubMed ID25869804
JournalMol Psychiatry
Linkwww.ncbi.nlm.nih.gov/pubmed/25869804
StudyGWAS for executive function and processing speed suggests involvement of the CADM2 gene.
Disease/TraitInformation processing speed
Initial sampleUp to 30,807 European ancestry individuals, up to 1,267 Erasmus Rucphen Family individuals, up to 535 Korkulan individuals, up to 417 Orcadian individuals, up to 311 Vis individuals
Replication sampleUp to 8,436 European ancestry individuals, up to 1,444 African American individuals
Region3p12.1
Chromosome idchr3
Chromosome position85555773
Reported geneCADM2
Mapped geneCADM2
Upstream gene id
Downstream gene id
SNP gene ids253559
Upstream gene distance
Downstream gene distance
SNP risk allelers17518584-T
SNPsrs17518584
Merged0
SNP id current17518584
Contextintron_variant
Intergenic0
Allele frequency0.64
P value0.000000003
Pvalue mlog8.52287874528033
P value text(LDST/DSST- age, sex, and education adjusted)
Or beta5.92
%95 Ci[NR] unit increase
PlatformAffymetrix, Illumina [up to 2357391] (imputed)
CNVN
Mapped traitinformation processing speed
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004363
Study accessionGCST002850
PubMed ID25644384
JournalMol Psychiatry
Linkwww.ncbi.nlm.nih.gov/pubmed/25644384
StudyGenetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53鈥?49).
Disease/TraitCognitive function
Initial sample51,719 European ancestry individuals 1,473 Erasmus Rupchen Family individuals, 327 Korculan individuals, 430 Orcadian individuals
Replication sampleNA
Region3p12.1
Chromosome idchr3
Chromosome position85555773
Reported geneCADM2
Mapped geneCADM2
Upstream gene id
Downstream gene id
SNP gene ids253559
Upstream gene distance
Downstream gene distance
SNP risk allelers17518584-?
SNPsrs17518584
Merged0
SNP id current17518584
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.000001
Pvalue mlog6
P value text
Or beta0.0282
%95 Ci[0.017-0.040] unit increase
PlatformAffymetrix, Illumina [2478500] (imputed)
CNVN
Mapped traitcognition
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003925
Study accessionGCST002774